AI Article Synopsis
- A semi-automated reconstruction of the L2/3 region of the mouse primary visual cortex was created using electron microscopy images, capturing various cell types and structures important for understanding visual processing.
- The data includes visual response characteristics of pyramidal cells and is available for public access, along with interactive tools for analysis.
- Research highlights how the organization of mitochondria and synapses relates to cell location, while predicting connectivity patterns in pyramidal cells correlates with their visual response strength and reliability.
Article Abstract
We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from ∼250 × 140 × 90 μm of electron microscopic images, including pyramidal and non-pyramidal neurons, astrocytes, microglia, oligodendrocytes and precursors, pericytes, vasculature, nuclei, mitochondria, and synapses. Visual responses of a subset of pyramidal cells are included. The data are publicly available, along with tools for programmatic and three-dimensional interactive access. Brief vignettes illustrate the breadth of potential applications relating structure to function in cortical circuits and neuronal cell biology. Mitochondria and synapse organization are characterized as a function of path length from the soma. Pyramidal connectivity motif frequencies are predicted accurately using a configuration model of random graphs. Pyramidal cells receiving more connections from nearby cells exhibit stronger and more reliable visual responses. Sample code shows data access and analysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337909 | PMC |
| http://dx.doi.org/10.1016/j.cell.2022.01.023 | DOI Listing |
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