With the development of nanotechnology and biotechnology, the nanomachine can be applied to the interior of the human body. In order to achieve the goal of completing complex tasks, measures to connect multiple nanomachines that can complete more simple tasks are taken. This can expand the ability of a single nanomachine to cooperate and share information to complete more complex tasks-namely, the emergence of the Body Area Network (BAN). In response to the requirements of building a BAN, we must first need to solve the communication problem between two nanomachines. Communication networks based on molecular communication (MC), known as "natural body area networks", are widely used in biomedical fields. With the considerable development of MC theory, it is urgent to set up an experimental platform to verify and guide theoretical modeling. In this paper, a nanomaterial-based MC platform is designed and built to simulate the cardiovascular system. The platform uses the diffusion of nanoscale pigment particles in water solution in silicone tube to achieve communication process and modulates binary sequence information to messenger molecules by on-off keying (OOK). The platform successfully transmits and receives a 17-bit binary sequence to prove its communication possibilities. To assess the platform capabilities, this paper tests the effects of different solution concentrations, pipeline flow rates, and pressure on platform communications. These factors can be used to expand the modulation schemes that the platform can implement. In future work, some nanomaterials that can be used for molecular communication can be applied to the platform to characterize their channel characteristics.
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http://dx.doi.org/10.3390/nano12040722 | DOI Listing |
Chem Asian J
January 2025
Institut po elektronikа Akad Emil Džakov B'lgarska akademiâ na naukite: Institut po elektronika Akademik Emil Dzakov B'lgarska akademia na naukite, Vihren Tautomeric devises and sensors, BULGARIA.
Dithienylethenes (DTE) are a rare class of photoswitches, which are capable of undergoing a fast photochemical cyclization leading to increased aromaticity of the closed isomer. At the same time in most of the tautomeric compounds the tautomeric state is strongly affected by the change in the aromaticity of the involved aromatic rings. Very recently it has been shown that the implementation of DTE moiety in salicylideneaniline leads to switching of the stable open form enol tautomer to thermodynamically stable keto tautomer upon cyclization.
View Article and Find Full Text PDFElife
January 2025
Department of Biology, Queens College, CUNY, New York, United States.
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the transforming growth factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) family, yet only a small number of direct target genes have been well characterized. In the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade. Here, we identify functional binding sites for SMA-3/Smad and its transcriptional partner SMA-9/Schnurri based on ChIP-seq peaks (identified by modEncode) and expression differences of nearby genes identified from RNA-seq analysis of corresponding mutants.
View Article and Find Full Text PDFJ Biomol Struct Dyn
March 2025
Department of Chemistry, Jamia Millia Islamia, New Delhi, India.
1,3,4-Oxadiazole-based heterocyclic analogs (3a-3m) were synthesized cyclization of Schiff bases with substituted aldehydes in the presence of bromine and acetic acid. The structural clarification of synthesized molecules was carried out with various spectroscopic techniques such as FT-IR,H and C-NMR, UV-visible spectroscopy, and mass spectrometry. antifungal activity was performed against , and and analogs 3g, 3i, and 3m showed potent MIC at 200 µg/ml and excellent ZOI measurements of 17-21 nm.
View Article and Find Full Text PDFF1000Res
January 2025
Immunology, University of Toronto, Toronto, Ontario, Canada.
Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease. Fibroblasts regulate the composition of the extracellular matrix (ECM), a 3-dimensional network of macromolecules that comprise the acellular milieu of tissues. Fibroblasts can directly and indirectly regulate immune responses by secreting ECM and ECM-bound molecules to shape tissue structure and influence organ function.
View Article and Find Full Text PDFBMC Med Imaging
January 2025
Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Level 1, Oxford Heart Centre, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
Background: Preterm birth (< 37 weeks' gestation) alters cerebrovascular development due to the premature transition from a foetal to postnatal circulatory system, with potential implications for future cerebrovascular health. This study aims to explore potential differences in the Circle of Willis (CoW), a key arterial ring that perfuses the brain, of healthy adults born preterm.
Methods: A total of 255 participants (108 preterm, 147 full-term) were included in the analysis.
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