Different control strategies are available for human machine interfaces based on electromyography (EMG) to map voluntary muscle signals to control signals of a remote controlled device. Complex systems such as robots or multi-fingered hands require a natural commanding, which can be realized with proportional and simultaneous control schemes. Machine learning approaches and methods based on regression are often used to realize the desired functionality. Training procedures often include the tracking of visual stimuli on a screen or additional sensors, such as cameras or force sensors, to create labels for decoder calibration. In certain scenarios, where ground truth, such as additional sensor data, can not be measured, e.g., with people suffering from physical disabilities, these methods come with the challenge of generating appropriate labels. We introduce a new approach that uses the EMG-feature stream recorded during a simple training procedure to generate continuous labels. The method avoids synchronization mismatches in the labels and has no need for additional sensor data. Furthermore, we investigated the influence of the transient phase of the muscle contraction when using the new labeling approach. For this purpose, we performed a user study involving 10 subjects performing online 2D goal-reaching and tracking tasks on a screen. In total, five different labeling methods were tested, including three variations of the new approach as well as methods based on binary labels, which served as a baseline. Results of the evaluation showed that the introduced labeling approach in combination with the transient phase leads to a proportional command that is more accurate than using only binary labels. In summary, this work presents a new labeling approach for proportional EMG control without the need of a complex training procedure or additional sensors.
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http://dx.doi.org/10.3390/s22041368 | DOI Listing |
Anal Chim Acta
May 2025
State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 639 Longmian Dadao, Nanjing, 211198, China. Electronic address:
Background: Traditional studies of protein responses to external stimuli primarily focus on changes in protein abundance, often overlooking the critical role of protein conformational alterations. To address this gap, we developed Protein Abundance and Conformation Analysis (PACA), an integrative method that quantifies both protein abundance and conformational changes. PACA combines conventional quantitative proteomics for abundance measurements with Target Response Accessibility Profiling (TRAP), a technique that captures conformational changes in situ by applying reductive dimethylation to label accessible lysine residues in living cells before lysis.
View Article and Find Full Text PDFBMJ Paediatr Open
March 2025
Children's Intensive Care Research Program, Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Background: Sepsis affects 25 million children and neonates annually, causing significant mortality and morbidity. Early identification and treatment are crucial for improving outcomes. Identifying children at risk is challenging due to clinical heterogeneity and overlap with other conditions.
View Article and Find Full Text PDFAnn Pharm Fr
March 2025
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, 400056, India. Electronic address:
Objectives: This research aims to analyse the regulatory frameworks for generic drug applications in the US, EU, India, Japan, and China comparing their filing requirements to identify gaps and areas for harmonization. Additionally, it focuses on examining common deficiencies in ANDA from FDA submissions in 2014-2023 to address issues, facilitating more efficient approvals and minimizing delays.
Material And Methods: The research involved analysing regulatory documents available on official websites, including the FDA, EMA, CDSCO, PMDA, and NMPA to achieve first objective.
Talanta
March 2025
The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics, Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:
The detection of glycosylation alterations is essential for elucidating the roles of glycan functions in biological processes and identifying potential disease biomarkers. Stable isotopic chemical labeling, coupled with mass spectrometry (MS), represents a powerful approach in quantitative glycomics. In this study, we synthesized a novel isotopic hydrazide pair, 2,6-Dimethyl-4-chinolincarbohydrazid (DMQCH) and its deuterium isomer DMQCH-d, via an efficient and cost-effective method, and applied it for the first time in MALDI-MS-based quantitative glycomics.
View Article and Find Full Text PDFForensic Sci Int
March 2025
Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku , Hamamatsu 431-3192, Japan.
Etizolam, a type of anxiolytic drug, is the most commonly abused drug among hypnotic/anxiolytic medications in Japan. Although there have been reports on the postmortem identification of etizolam in the blood, the detailed distribution of etizolam among organs in an abuse case has not been reported. In this study, we examined etizolam concentrations in the blood and organs obtained from etizolam-related autopsy cases using the surrogate analyte approach (SAA) method, which can be analytically used without blank samples.
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