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Identification of high-risk oral leukoplakia (OLK) using combined Raman spectroscopic analysis of brush biopsy and saliva samples: A proof of concept study.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Centre for Radiation and Environmental Science, FOCAS Research Institute, Technological University Dublin, City Campus, Dublin, Ireland; School of Physics, Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin, Ireland.
The gold standard method of diagnosis of oral leukoplakia (OLK) is a tissue biopsy followed by histological examination. Raman spectroscopic studies of cytological brush biopsy and saliva samples have previously been shown to differentiate low (no and mild dysplasia) and high risk (moderate and severe dysplasia) OLKs, discriminant models of cellular samples achieving higher specificity, whereas those based on saliva samples achieved higher sensitivity. The current study combines the spectral data sets of cell and saliva samples in an attempt to improve the overall efficiency of the discriminating models.
View Article and Find Full Text PDFElectrochemical insights into the direct dissolution of impure sphalerites and their partial oxidation in an acidic environment.
Sci Rep
January 2025
Department of Mining and Explosives Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
This study examined the electrodissolution mechanism of five impure sphalerite samples, which differ significantly in purity levels, along with their partially oxidized counterparts in a 0.5 M HSO. Partially oxidized samples were prepared through an incomplete leaching of sphalerite using HSO with Fe(SO).
View Article and Find Full Text PDFTotal saponin extracts of Pseudostellaria heterophylla ameliorates meibomian gland dysfunction through SCD1/SPT1/ceramide axis.
J Ethnopharmacol
January 2025
The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen, China; Xiamen Key Laboratory of Chiral Drugs, Xiamen, China. Electronic address:
Ethnopharmacological Relevance: Pseudostellaria heterophylla (Tài Zǐ Shēn, TZS) is a traditional Chinese medicine with spleen and qi benefits. Its immunomodulatory, anti-fatigue, anti-stress, and lipid metabolism regulation effects have been clinically confirmed, but its role in meibomian gland dysfunction (MGD) is still unclear.
Aim Of The Study: This study aims to investigate the effect and mechanism of action of TZS in treating MGD.
Synergistic SERS Enhancement of Highly Sensitive and Reusable rGO-Ag-ZrO Thin Film Nanocomposite to Detect Synthetic Textile Dyes.
Langmuir
January 2025
Centre for Nano and Soft Matter Sciences, Shivanapura, Dasanapura Hobli, Bangalore 562162, India.
The textile industry is one of the main industries that benefited from the industrial revolution. Therefore, discharging of dyes from textile, paper, plastic, and rubber industries is inevitable. This colored wastewater prevents sunlight penetration and highly affects water sources.
View Article and Find Full Text PDFUltra-Sensitive Detection of Bacterial Spores via SERS.
ACS Sens
January 2025
Department of Physics, Umeå University, Umeå SE-901 87, Sweden.
Bacterial spores are highly resilient and capable of surviving extreme conditions, making them a persistent threat in contexts such as disease transmission, food safety, and bioterrorism. Their ability to withstand conventional sterilization methods necessitates rapid and accurate detection techniques to effectively mitigate the risks they present. In this study, we introduce a surface-enhanced Raman spectroscopy (SERS) approach for detecting spores by targeting calcium dipicolinate acid (CaDPA), a biomarker uniquely associated with bacterial spores.
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