One-loop correction to the power spectrum in generic single-field inflation is calculated by using standard perturbation theory. Because of the enhancement inversely proportional to the observed red tilt of the spectral index of curvature perturbation, the correction turns out to be much larger than previously anticipated. As a result, the primordial non-Gaussianity must be much smaller than the current observational bound in order to warrant the validity of cosmological perturbation theory.
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