Objectives: HIV infection is associated with ectopic fat deposition, which leads to chronic inflammation and cardiometabolic dysregulation. We assessed the epicardial adipose tissue (EAT) volume and its associated factors among people with HIV (PWH).
Design: A cross-sectional study.
Methods: We conducted a cross-sectional study among PWH aged at least 50 years and age-matched and sex-matched HIV-negative older individuals in Bangkok, Thailand. Participants underwent a noncontrast, cardiac computed tomography (CT) scan to assess coronary artery calcium (CAC) score and EAT between March 2016 and June 2017. Multivariate linear regression analyses were used to investigate HIV-related factors, cardiac and metabolic markers associated with EAT volume.
Results: Median age was 55 years [interquartile range (IQR) 52-60] and 63% were men. Median duration of antiretroviral therapy (ART) was 16 years with 97% had HIV-1 RNA less than 50 copies/ml and median CD4 + cell count of 617 cells/μl. Median EAT volume was significantly higher in PWH [99 (IQR 75-122) cm 3 ] than HIV-negative individuals [93 (IQR 69-117) cm 3 ], P = 0.022. In adjusted model, factors associated with EAT volume included male sex ( P = 0.045), older age ( P < 0.001), abnormal waist circumference ( P < 0.001) and HOMA-IR ( P = 0.01). In addition, higher CAC score was independently associated with EAT volume. Higher mean EAT volume was seen in PWH with severe liver steatosis than those without steatosis ( P = 0.018). In adjusted PWH-only model, duration of HIV was significantly associated with higher EAT volume ( P = 0.028).
Conclusion: In an aging cohort, PWH had higher EAT volume than HIV-negative controls. EAT was also independently associated with central fat accumulation, insulin resistance, liver steatosis and CAC score.
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http://dx.doi.org/10.1097/QAD.0000000000003204 | DOI Listing |
Quant Imaging Med Surg
December 2024
Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Background: Radiofrequency catheter ablation (RFCA) represents an important treatment option for atrial fibrillation (AF); however, the recurrence rate following surgery is relatively high. This study aimed to predict the recurrence of AF after RFCA using interpretable machine learning models that combined the triglyceride-glucose (TyG) index and the quantification of left atrial epicardial and pericoronary adipose tissue.
Methods: This retrospective study included 325 patients with AF who underwent their first successful RFCA, among whom 79 had confirmed recurrence.
Cardiovasc Diabetol
December 2024
Department of Cardiology, Sichuan University, Chengdu, Sichuan Province, 610041, People's Republic of China.
Background: Epicardial adipose tissue (EAT) has been suggested to play paradoxical roles in patients with heart failure. The role of EAT in dilated cardiomyopathy (DCM) patients remains unclear. We aimed to assess the associations between the dynamic changes EAT and left ventricular reverse remodeling (LVRR) in DCM patients based on baseline and follow-up CMR.
View Article and Find Full Text PDFJ Am Heart Assoc
December 2024
Department of Radiology Shandong Provincial Hospital, Shandong University Jinan Shandong China.
Background: Epicardial adipose tissue (EAT) accumulation is thought to play a role in the pathophysiology of heart failure (HF) with mid-range ejection fraction and HF with preserved ejection fraction, but its effect on outcome is unknown.
Methods And Results: A total of 692 patients with HF with mid-range ejection fraction or HF with preserved ejection fraction who underwent cardiovascular magnetic resonance at 2 medical centers in China between October 2016 and October 2022 were included in this study. EAT volume and extracellular volume were calculated using cardiovascular magnetic resonance.
J Child Psychol Psychiatry
December 2024
Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
Radiography (Lond)
November 2024
Department of Cardiology, Ibara City Hospital, 1186 Ibara-tyou, Ibara-city, Okayama, 715-0019 Japan.
Introduction: The abundance of epicardial adipose tissue (EAT) correlates with the extent and severity of coronary artery disease (CAD). If the quantity of EAT varies between diastole and systole during an ECG-synchronized volume scan, it can potentially affect the diagnostic accuracy of CAD. The aim of this study was to compare the EAT volume between the diastolic and systolic phases during an ECG-gated volume scan of patients with or without CAD.
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