AI Article Synopsis
- The text discusses a genus of Amoebozoa that includes harmful species found in the intestines, focusing on gene regulation from an evolutionary viewpoint.
- Research involved profiling transcriptomes of closely related species, identifying transcription start sites (TSS) and polyadenylation sites (PAS) to analyze gene regulatory sequences.
- A key finding was the prevalence of antisense transcription within gene coding sequences, particularly in genes related to processes critical for species that infect the human intestine, hinting at a conserved gene regulatory system.
Article Abstract
is a genus of Amoebozoa that includes the intestine-colonizing pathogenic species . To understand the basis of gene regulation in from an evolutionary perspective, we have profiled the transcriptomes of its closely related species , and Genome-wide identification of transcription start sites (TSS) and polyadenylation sites (PAS) revealed the similarities and differences of their gene regulatory sequences. In particular, we found the widespread initiation of antisense transcription from within the gene coding sequences is a common feature among all species. Interestingly, we observed the enrichment of antisense transcription in genes involved in several processes that are common to species infecting the human intestine, e.g., the metabolism of phospholipids. These results suggest a potentially conserved and compact gene regulatory system in .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874941 | PMC |
| http://dx.doi.org/10.3390/microorganisms10020396 | DOI Listing |
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