In osteoporotic fractures of the spine with resulting kyphosis and threatening compression of neural structures, therapeutic decisions are difficult. The posterior vertebral column resection (pVCR) has been described by different authors as a surgical treatment in a single-stage posterior procedure. The aim of this study is to evaluate midterm outcomes of patients treated by pVCR due to severe osteoporotic fractures. Retrospective data analysis of all the patients treated for osteoporotic fractures by pVCR from 2012-2020 at two centers was performed. Demographic data, visual analog scale (VAS), Frankel scale (FS), Karnofsky performance status (KPS), radiological result and spinal fusion rates were evaluated. A total of 17 patients were included. The mean age was 70 ± 10.2 y. The mean VAS decreased significantly from 7.7 ± 2.8 preoperatively to 3.0 ± 1.6 at last follow-up ( < 0.001) and the segmental kyphosis decreased from 29.4 ± 14.1° to 7.9 ± 8.0° ( < 0.001). The neurologic function on the FS did not worsen in any and improved in four of the patients. The median KPS remained stable over the whole observation period (70% vs. 70%). Spinal fusion was observed in nine out of nine patients who received CT follow-up >120 days after index surgery. This study showed that pVCR is a safe surgical technique with few surgical complications and no neurological deterioration considering the cohort. The patients' segmental kyphosis and VAS improved significantly, while the KPS remained stable.
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http://dx.doi.org/10.3390/medicina58020277 | DOI Listing |
Alzheimers Dement
December 2024
University of California, San Francisco, San Francisco, CA, USA.
Background: Poor sleep health is associated with cognitive impairment (CI) in older adults. The cardiopulmonary coupling (CPC) sleep spectrogram, which estimates the sleep state modulated synchronization between heart rate variability and respiration, is an increasingly recognized measure of sleep stability. However, little is known about the longitudinal association between CPC measures of sleep stability and risk of incident CI.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of California, San Francisco, San Francisco, CA, USA.
Background: Individuals with dementia frequently exhibit disturbed sleep electroencephalography (EEG) microstructures, including spindles and slow oscillations. We have previously developed a sleep EEG-based brain age index (BAI), which integrates multiple sleep EEG microstructures and has been associated with prevalent dementia in clinical populations. Here, we aim to determine if BAI is associated with incident cognitive impairment (CI) in a community population of older men, and its discrimination capability as a digital biomarker.
View Article and Find Full Text PDFClin Rehabil
January 2025
Department of Nursing, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Objective: To explore the status of kinesophobia in patients with osteoporotic vertebral compression fractures and analyze the influencing factors of different kinesophobia profiles.
Design: Cross-sectional survey study.
Participants: A total of 245 patients with osteoporotic vertebral compression fractures who underwent surgical treatment at our Department of Orthopedics between January 2023 and March 2024 were selected.
J Orthop Surg Res
January 2025
Department of Orthopaedic and Trauma Surgery, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Background: Osteoporosis, a skeletal disorder affecting nearly 20% of the global population, poses a significant health concern, with osteoporotic vertebral body fractures (VBF) representing a common clinical manifestation. The impact of osteoporotic sintering fractures in the thoracolumbar spine on the sagittal lumbar profile is incompletely understood and may lead to the onset of clinical symptoms in previously asymptomatic patients.
Methods: This retrospective single-center study analyzed data from patients presenting with osteoporotic spine fractures between 2017 and 2022.
Arch Osteoporos
January 2025
Department of Endocrinology and Diabetes, Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Unlabelled: Our study investigated trends in osteoporosis management in Xiamen from 2012 to 2021, revealing improvements in screening and treatment, although medication use remained low. Additionally, we identified factors that may influence medication use and emphasized the importance of effective osteoporosis management strategies.
Purpose: The goal of the current study is to explore trends in assessment, diagnosis after fragility fractures, and osteoporosis treatment among hospitalized patients in Xiamen, China, between 2012 and 2021.
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