The case of a 73-year-old woman with extensive abdominal actinomycosis is reported. It appears to be the first case of abdominal actinomycosis in which endoscopic and serologic investigations have been performed before and after medical therapy. Ultrasonography, CT scan and surgical exploration revealed an extensive inflammatory tumor of the sigmoid colon involving the urinary bladder and uterus. Histologic examination revealed typical sulfur granules. Longterm highdose therapy with penicillin was performed.

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