Background: Observational studies on the association between neuroticism and coronary artery disease (CAD) are still rare, and the results of existing studies are not consistent. The present study aimed to explore causal associations of neuroticism with CAD.
Methods: The summary-level data of GWAS for neuroticism and 12 items used to assess neuroticism were extracted from the UK Biobank, and included up to 380,506 participants. The general data for CAD were obtained from the CARDIoGRAMplusC4D consortium, which assembled 60,801 CAD patients and 123,504 non-cases. Single-nucleotide polymorphisms associated with neuroticism and 12 items at genome-wide significance were explored as instrumental variables. Two-sample Mendelian randomization (TSMR) analyses were performed to evaluate causal associations amongst the genetically predicted neuroticism and 12 items with CAD.
Results: The present TSMR study did not reveal the genetic association of neuroticism with CAD. The calculated ORs for CAD using inverse-variance weighted, weighted median, and MR-Egger analysis were 1.12 (-value = 0.187), 0.99 (-value = 0.943), and 0.82 (-value = 0.683), respectively. Further TSMR analysis of 12 dichotomous items for assessing neuroticism suggested that mood swings genetically increased the risk of CAD (OR = 1.67, -value < 0.001).
Conclusions: This study reported no genetically causal association of neuroticism with CAD. The present study also found that mood swings may genetically increase the risk of CAD. These findings may highlight the potential of mood control as a preventive measure for CAD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877774 | PMC |
| http://dx.doi.org/10.3390/jpm12020288 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association Between Postpartum Depression and Personality Traits Among Japanese Postpartum Mothers and Fathers.
J Clin Med
December 2024
Department of Clinical Psychology, Graduate School of Medicine, Kagawa University, Takamatsu 761-0793, Japan.
: Although numerous investigations have been conducted on postpartum depression, studies on the association between postpartum depression and personality traits of mothers and fathers are lacking. This study aimed to examine the association between postpartum depression and the Big Five personality models among Japanese mothers and fathers at one-month health check-ups. : The participants were 82 couples, and they responded to the Edinburgh Postnatal Depression Scale (EPDS), the Japanese version of the Ten-Item Personality Inventory, and the Quality of Marriage Index (QMI).
View Article and Find Full Text PDFActor-Partner Effects of Personality Traits and Psychological Flexibility on Psychological Distress Among Couples Coping with Cancer.
Behav Sci (Basel)
December 2024
Department of Psychology, Bar-Ilan University, Ramat Gan 5290002, Israel.
In this study, we applied the actor-partner interdependence model (APIM) to explore the associations between personality traits (Big Five) and psychological flexibility, on the one hand, and depression and anxiety, on the other hand, among patients with cancer and their spouses. Method: Forty-six patient-spouse dyads (N = 92) completed the anxiety and depression scales from the Patient-Reported Outcomes Measurement Information System (PROMIS), the ten-item personality inventory (TIPI), and the psychological flexibility scale (AAQ-2). Multilevel APIM models, adjusted for multiple testing, showed that neuroticism and psychological flexibility had actor effects on patients' depression and anxiety.
View Article and Find Full Text PDFConnecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity.
Nat Commun
January 2025
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Identifying cell types and brain regions critical for psychiatric disorders and brain traits is essential for targeted neurobiological research. By integrating genomic insights from genome-wide association studies with a comprehensive single-cell transcriptomic atlas of the adult human brain, we prioritized specific neuronal clusters significantly enriched for the SNP-heritabilities for schizophrenia, bipolar disorder, and major depressive disorder along with intelligence, education, and neuroticism. Extrapolation of cell-type results to brain regions reveals the whole-brain impact of schizophrenia genetic risk, with subregions in the hippocampus and amygdala exhibiting the most significant enrichment of SNP-heritability.
View Article and Find Full Text PDFHealthcare users' evaluation of general practice - a survey among Danish men aged 45 to 70 years.
BJGP Open
January 2025
Department of Clinical Research, University of Southern Denmark and Open Patient data Explorative Network, Odense University Hospital, Odense, Denmark.
Background: Knowledge about healthcare users' evaluation of general practice is relatively limited.
Aim: We aimed to investigate evaluations in Danish men of general practice healthcare and of different aspects of general practitioners' (GPs) communication with patients.
Design & Setting: Secondary analyses of data from a web-based survey in 6756 Danish men aged 45-70 years (30% response rate) using municipality-level information from registries, self-reported sociodemographic data, personality characteristics, and five-point Likert scale evaluations of healthcare and communication in general practice.
Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial.
Am J Psychiatry
January 2025
Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York (Pagni, Zeifman, Mennenga, Carrithers, Goldway, O'Donnell, Ross, Bogenschutz); School of Life Sciences, Arizona State University, Tempe (Mennenga); Department of Psychology, New York University, New York (Goldway); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Bhatt).
Article Synopsis
- The study explored how psilocybin-assisted therapy (PAT) impacts personality traits in people with alcohol use disorder (AUD), hypothesizing it would reduce trait impulsiveness and improve drinking behavior.
- Eighty-four AUD patients were divided into two groups (psilocybin vs. placebo) and assessed for changes in personality traits over time, finding significant personality shifts in the psilocybin group, including reduced neuroticism and increased openness.
- The results indicated that lower impulsiveness correlated with decreased alcohol consumption, particularly among those who drank at risk before treatment, pointing to potential benefits of PAT in addressing both personality and drinking behaviors.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!