AI Article Synopsis
- Dilated cardiomyopathy (DCM) is a leading cause of heart failure with a 20% mortality rate in 5 years, yet there's a lack of validated risk assessment tools for these patients.
- A study of 735 DCM patients calculated their mortality risk using the Krakow DCM Risk Score and followed them for about 42 months.
- The results showed that the Krakow DCM Risk Score effectively identified high-risk patients, with those having a >6% 2-year mortality risk experiencing significantly higher death rates compared to lower-risk patients.
Article Abstract
Background: One of the most common causes of heart failure is dilated cardiomyopathy (DCM). In DCM, the mortality risk is high and reaches approximately 20% in 5 years. A patient's prognosis should be established for appropriate HF management. However, so far, no validated tools have been available for the DCM population.
Methods: The study population consisted of 735 DCM patients: 406 from the derivation cohort (previously described) and 329 from the validation cohort (from 2009 to 2020, with outcome data after a mean of 42 months). For each DCM patient, the individual mortality risk was calculated based on the Krakow DCM Risk Score.
Results: During follow-up, 49 (15%) patients of the validation cohort died. They had shown significantly higher calculated 1-to-5-year mortality risks. The Krakow DCM Risk Score yielded good discrimination in terms of overall mortality risk, with an AUC of 0.704-0.765. Based on a 2-year mortality risk, patients were divided into non-high (≤6%) and high (>6%) mortality risk groups. The observed mortality rates were 8.3% ( = 44) vs. 42.6% ( = 75), respectively (HR 3.37; 95%CI 1.88-6.05; < 0.0001).
Conclusions: The Krakow DCM Risk Score was found to have good predictive accuracy. The 2-year mortality risk > 6% has good discrimination for the identification of high-risk patients and can be applied in everyday practice.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879244 | PMC |
| http://dx.doi.org/10.3390/jpm12020236 | DOI Listing |
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