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Relevance of Biotin Deficiency in Patients with Inflammatory Bowel Disease and Utility of Serum 3 Hydroxyisovaleryl Carnitine as a Practical Everyday Marker. | LitMetric

AI Article Synopsis

  • - Biotin, a B vitamin with anti-inflammatory effects, was found to be deficient in mice with colitis, and its supplementation could reduce inflammatory symptoms by blocking the activation of NF-κB, suggesting a potential therapeutic role for biotin in inflammatory bowel disease (IBD).
  • - A study analyzed serum samples from 138 IBD patients and 80 healthy individuals to assess biotin status; results showed higher levels of 3-hydroxyisovaleryl carnitine (3HIVc) in IBD patients, indicating more frequent biotin deficiency compared to controls.
  • - The research concludes that biotin deficiency may be linked to IBD development but doesn't correlate with disease activity or type, highlighting the importance of

Article Abstract

Background: Biotin, a water-soluble B vitamin, has demonstrable anti-inflammatory properties. A biotin-deficient diet induced a colitis-like phenotype in mice, alleviable by biotin substitution. Mice with dextran sulfate sodium (DSS)-induced colitis showed biotin deficiency and diminished levels of sodium-dependent multivitamin transporter, a protein involved in biotin absorption. Biotin substitution induced remission by reducing activation of NF-κB, a transcription factor involved in intestinal permeability and inflammatory bowel disease (IBD). We investigated for the first time a possible clinical role of biotin status in IBD.

Methods: In a comparative, retrospective, cross-sectional study, serum samples of 138 patients with IBD (67 female; 72 Crohn's disease (CD), 66 ulcerative colitis (UC)) aged 18-65 years and with a mean age (±SD) of 42.5 ± 14.3 years as well as 80 healthy blood donors (40 female; 40.0 ± 10.0 years; range 20-60 years) were analyzed. Inflammation was defined as hsCRP ≥5 mg/L, and to determine biotin status, serum 3-hydroxyisovaleryl carnitine (3HIVc) levels were measured by LC-MS/MS.

Results: A total of 138 patients with IBD (67f; 72CD/66 UC; 42.5 ± 14.3 years) were enrolled: 83/138 had inflammation. Mean serum 3HIVc levels were significantly higher in IBD patients but unaffected by inflammation. Biotin deficiency (95th percentile of controls: >30 nmol/L 3HIVc) was significantly more common in IBD patients versus controls.

Conclusion: High serum 3HIVc levels and biotin deficiency were associated with IBD but not inflammatory activity or disease type. Our findings suggest biotin may play a role as cause or effect in IBD pathogenesis. Routine assessment and supplementation of biotin may ameliorate IBD and support intestinal integrity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877558PMC
http://dx.doi.org/10.3390/jcm11041118DOI Listing

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