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Serum Levels of MMP-8 and MMP-9 as Markers in Chronic Subdural Hematoma. | LitMetric

Serum Levels of MMP-8 and MMP-9 as Markers in Chronic Subdural Hematoma.

J Clin Med

Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518000, China.

Published: February 2022

AI Article Synopsis

Article Abstract

Chronic subdural hematoma (CSDH) is a common neurological disease that involves the collection of blood products in the subdural space. The progression of CSDH is an angiogenic and inflammatory process, but the multifactorial mechanisms underlying CSDH are still not fully understood. We aimed to identify one or more factors that may play an important role in the development of CSDH. We enrolled 83 patients with CSDH, including 17 postoperative patients, and analyzed 20 markers in the hematoma fluid and peripheral blood of each patient. Overall differential gene expression was examined to identify the representative markers. The concentration of MMP-8 was significantly lower in the postoperative group than in the preoperative group. The concentration of MMP-9 was significantly higher in the postoperative group than in the preoperative group. These findings indicate that MMP-8 and MMP-9 may play important roles in the pathophysiology of CSDH. Understanding the pathways associated with CSDH may provide insights for improving disease outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878690PMC
http://dx.doi.org/10.3390/jcm11040902DOI Listing

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