Kidney disease is a major public health concern that has only recently emerged. Toxins are removed from the body by the kidneys through urine. In the early stages of the condition, the patient has no problems, but recovery is difficult in the later stages. Doctors must be able to recognize this condition early in order to save the lives of their patients. To detect this illness early on, researchers have used a variety of methods. Prediction analysis based on machine learning has been shown to be more accurate than other methodologies. This research can help us to better understand global disparities in kidney disease, as well as what we can do to address them and coordinate our efforts to achieve global kidney health equity. This study provides an excellent feature-based prediction model for detecting kidney disease. Various machine learning algorithms, including k-nearest neighbors algorithm (KNN), artificial neural networks (ANN), support vector machines (SVM), naive bayes (NB), and others, as well as Re-cursive Feature Elimination (RFE) and Chi-Square test feature-selection techniques, were used to build and analyze various prediction models on a publicly available dataset of healthy and kidney disease patients. The studies found that a logistic regression-based prediction model with optimal features chosen using the Chi-Square technique had the highest accuracy of 98.75 percent. White Blood Cell Count (Wbcc), Blood Glucose Random (bgr), Blood Urea (Bu), Serum Creatinine (Sc), Packed Cell Volume (Pcv), Albumin (Al), Hemoglobin (Hemo), Age, Sugar (Su), Hypertension (Htn), Diabetes Mellitus (Dm), and Blood Pressure (Bp) are examples of these traits.
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http://dx.doi.org/10.3390/healthcare10020371 | DOI Listing |
Environ Int
December 2024
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:
Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived from the Aristolochia genus and is known to cause significant damage to renal tubular epithelial cells. Genome-wide screening has proven to be a powerful tool in identifying critical genes associated with the toxicity of exogenous substances. To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line.
View Article and Find Full Text PDFClin Exp Nephrol
December 2024
Division of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, 162-8666, Japan.
Background: Whether diabetic retinopathy (DR) can predict kidney disease progression in individuals with diabetes remains unclear. Furthermore, there are only a limited number of studies investigating the association between DR and kidney outcomes classified according to baseline kidney function and albuminuria status. Here, we examined the association of DR with kidney disease progression in individuals with type 2 diabetes.
View Article and Find Full Text PDFInt Urol Nephrol
December 2024
Department of Pediatrics, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China.
Purpose: Henoch-Schönlein purpura nephritis (HSPN) has a poor prognosis and variable pathophysiology. The present study aimed to analyze the kidney injury, clinicopathology, and prognosis of HSPN children.
Methods: This retrospective study examined 249 children with HSPN.
J Nephrol
December 2024
Vanderbilt Institute for Global Health (VIGH), Nashville, TN, USA.
Background: Pregnancy-Related Acute Kidney Injury (PRAKI) is an important contributor to maternal-fetal morbidity and mortality. The burden of PRAKI in sub-Saharan Africa is not well documented. We conducted a systematic literature review and meta-analysis to estimate the prevalence of PRAKI in sub-Saharan Africa.
View Article and Find Full Text PDFUrolithiasis
December 2024
Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan.
The early stages of kidney crystal formation involve inflammation and hypoxia-induced cell injury; however, the role of the hypoxic response in kidney crystal formation remains unclear. This study investigated the effects of a prolyl hydroxylase domain inhibitor (roxadustat) on renal calcium oxalate (CaOx) crystal formation through in vitro and in vivo approaches. In the in vitro experiment, murine renal tubular cells (RTCs) were exposed to varying roxadustat concentrations and CaOx crystals.
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