AI Article Synopsis
- The study focuses on the effects of γ-heptalactone on the production of biologically active compounds, specifically Monascus pigments (MPs) and monacolin K (MK), during M1 fermentation.
- Results showed that adding 50 μM γ-heptalactone significantly increased the yields of yellow, orange, and red MPs by 115.70%, 141.52%, and 100.88%, respectively, while 25 μM led to a 62.38% increase in MK yield compared to the control group.
- Gene expression analysis indicated that γ-heptalactone treatment significantly upregulated the genes responsible for the synthesis of both MPs and MK, while also altering the mycel
Article Abstract
is used widely in Asian countries and produces various biologically active metabolites, such as Monascus pigments (MPs) and monacolin K (MK). In this study, the effect of γ-heptalactone on secondary metabolites and mycelial growth during M1 fermentation was investigated. After the addition of 50 μM γ-heptalactone, the yields of MPs (yellow, orange, and red) reached maxima, increased by 115.70, 141.52, and 100.88%, respectively. The 25 μM γ-heptalactone groups showed the highest yield of MK was increased by 62.38% compared with that of the control. Gene expression analysis showed that the relative expression levels of MPs synthesis genes (, , , , , , , and /) were significantly upregulated after γ-heptalactone treatment. The relative expression levels of MK synthesis genes (, , , and ) were significantly affected. The mycelium samples treated with γ-heptalactone exhibited more folds and swelling than that in the samples of the control group. This study confirmed that the addition of γ-heptalactone has the potential to induce yields of MPs and MK, and promote the expression of biosynthesis genes, which may be related to the transformation of mycelial morphology in .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880682 | PMC |
| http://dx.doi.org/10.3390/jof8020179 | DOI Listing |
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