In this work, we explore the relevant methodology for the investigation of interacting systems with contact interactions, and we introduce a class of zonal estimators for path-integral Monte Carlo methods, designed to provide physical information about limited regions of inhomogeneous systems. We demonstrate the usefulness of zonal estimators by their application to a system of trapped bosons in a quasiperiodic potential in two dimensions, focusing on finite temperature properties across a wide range of values of the potential. Finally, we comment on the generalization of such estimators to local fluctuations of the particle numbers and to magnetic ordering in multi-component systems, spin systems, and systems with nonlocal interactions.
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http://dx.doi.org/10.3390/e24020265 | DOI Listing |
Heart Rhythm
January 2025
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Background: Although drug interactions between clarithromycin/erythromycin/fluconazole and direct oral anticoagulants (DOACs) are mechanistically plausible, it is uncertain whether they are clinically relevant.
Objective: To investigate the association between co-prescribed DOACs and antimicrobials and bleeding, cardiovascular disease and mortality.
Methods: We identified DOAC users in the Clinical Practice Research Datalink Aurum from 1/1/2011-29/3/2021.
Pharmaceuticals (Basel)
December 2024
Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
This study aimed to develop an optimized and wide concentration range HPLC-UV method for fluconazole (FLU) determination and its adaptation for pharmacokinetics (PK) studies in the pediatric population. The following parameters of chromatographic separation were optimized: retention time, tailing factor, peak height, and the sample preconditioning parameter, such as recovery. The optimization process involved the use of a central composite design (CCD) and Box-Behnken design (BBD) in the design of experiments (DoE) approach and a multilayer perceptron (MLP) for artificial neural network (ANN) application.
View Article and Find Full Text PDFExpert Rev Anti Infect Ther
January 2025
Pathogenic Yeast Research Group, Department of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
Introduction: There is a rise in the emergence of multidrug resistant fungal pathogens worldwide, including in Africa.
Method: This systematic review summarized the published data on the mechanisms and epidemiology of antifungal resistance in species in Africa between 2000 and early 2024.
Result: Seventeen reports from seven African countries were analyzed but due to the paucity of data, the prevalence of antifungal resistant isolates in Africa could not be estimated.
Sci Rep
December 2024
Climate and Global Dynamics Laboratory, NSF National Center for Atmospheric Research, 1850 Table Mesa Drive, Boulder, CO, 80305, USA.
The warm Western Boundary Currents (WBCs) and their zonal extensions are persistent, deep, strong and narrow oceanic currents. They are known to anchor and energize the Extra-Tropical storm tracks by frontal thermal air-sea interactions. However, even in the latest generation of climate models, WBCs are characterized by large biases, and both the present storm-track activity and its recent intensification are poorly estimated.
View Article and Find Full Text PDFmBio
December 2024
Unidad Mixta Infección y Salud Pública FISABIO-Universidad de Valencia, Valencia, Spain.
The rapid increase in infections caused by the emerging fungal pathogen is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is particularly relevant, as most of its strains exhibit resistance to fluconazole, reducing the therapeutic alternatives and provoking outbreaks that are difficult to control. In this study, we have investigated the phylogenetic structure of clade III by analyzing a global collection of 566 genomes.
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