The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872343 | PMC |
| http://dx.doi.org/10.3390/genes13020378 | DOI Listing |
Publication Analysis
Top Keywords
prostate cancer
16
epigenetic epitranscriptomic
8
dna rna
8
epitranscriptomic control
4
prostate
4
control prostate
4
cancer
4
cancer initiation
4
initiation prostate
4
cancer long
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!