AI Article Synopsis
- Cardiovascular diseases are the top cause of death for individuals with diabetes, highlighting the significance of diabetic cardiomyopathy (DC) as a unique form of heart failure that arises without preexisting cardiovascular issues.
- Chronic high blood sugar levels, high insulin levels, insulin resistance, and inflammation are key factors that contribute to the development of diabetic cardiomyopathy.
- Current approaches to managing DC include lifestyle changes for healthier eating and exercise, along with advanced diabetes treatments aimed at protecting heart function and improving cardiovascular health in type 2 diabetes patients.
Article Abstract
Cardiovascular diseases are the leading cause of death in people with diabetes. Diabetic cardiomyopathy (DC) is an important complication of diabetes and represents a distinct subtype of heart failure that occurs in absence of cardiovascular diseases. Chronic hyperglycemia and hyperinsulinemia along with insulin resistance and inflammatory milieu are the main mechanisms involved in the pathophysiology of DC. Changes in lifestyle favoring healthy dietary patterns and physical activity, combined with more innovative anti-diabetes therapies, are the current treatment strategies to safeguard the cardiovascular system. This review aims at providing an updated comprehensive overview of clinical, pathogenetic, and molecular aspects of DC, with a focus on the effects of anti-hyperglycemic drugs on the prevention of pump dysfunction and consequently on cardiovascular health in type 2 diabetes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961546 | PMC |
| http://dx.doi.org/10.3390/biom12020272 | DOI Listing |
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