In recent years, improvements in imaging techniques have profoundly facilitated the diagnosis of pathologies of the maxillofacial district [...].
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http://dx.doi.org/10.3390/diagnostics12020536 | DOI Listing |
Am J Cancer Res
December 2024
School of Basic Medical Sciences, Jiamusi University No. 258, Xuefu Street, Xiangyang District, Jiamusi 154007, Heilongjiang, China.
Breast cancer is the most common malignant tumour in women, with more than 685,000 women dying of breast cancer each year. The heterogeneity of breast cancer complicates both treatment and diagnosis. Traditional methods based on histopathology and hormone receptor status are now no longer sufficient.
View Article and Find Full Text PDFAm J Cancer Res
December 2024
Department of Pharmacology and Toxicology, Medical College of Wisconsin Milwaukee, Wisconsin 53226, USA.
Cancer cell overexpresses numerus proteins, however, how these up-regulated proteins, especially those enzymatically opposite kinases and phosphatases, act together to promote oncogenesis is unknown. Here, we reported that protein tyrosine phosphatase H1 (PTPH1) is a scaffold protein for receptor tyrosine kinase (HER2) to potentiate breast tumorigenesis. PTPH1 utilizes its PDZ domain to bind HER2, p38γ, PBK, and YAP1 and to increase HER2 nuclear translocation, stemness, and oncogenesis.
View Article and Find Full Text PDFBio Protoc
January 2025
Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Riken, 2-1 Hirosawa, Wako Saitama, Japan.
Cytosolic peptide:-glycanase (PNGase/NGLY1 in mammals), an amidase classified under EC:3.5.1.
View Article and Find Full Text PDFCureus
December 2024
Faculty of Medicine, University of Patras, Rion, GRC.
General practice/family medicine is a primary healthcare discipline that focuses on providing comprehensive, patient-centered care to individuals and families across their lifespan. This study aimed to assess the implementation of artificial intelligence (AI) in general practice/family medicine regarding the 12 characteristics of its discipline as described in the recently revised European Definition of General Practice/Family Medicine. AI has the potential to revolutionize family medicine practice by improving the accuracy, efficiency, and effectiveness of various clinical tasks.
View Article and Find Full Text PDFJACC Asia
December 2024
Primary Aldosteronism Center in National Taiwan University Hospital, TAIPAI (Taiwan Primary Aldosteronism Investigation) Study Group, Taiwan.
Background: In this study, we developed and validated machine learning models to predict primary aldosteronism (PA) in hypertensive East-Asian patients, comparing their performance against the traditional saline infusion test. The motivation for this development arises from the need to provide a more efficient and standardized diagnostic approach, because the saline infusion test, although considered a gold standard, is often cumbersome, is time-consuming, and lacks uniform protocols. By offering an alternative diagnostic method, this study seeks to enhance patient care through quicker and potentially more reliable PA detection.
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