AI Article Synopsis
- The text discusses a gram-negative pathogen that is opportunistic and can lead to infections, especially in people with weakened immune systems.* -
- This pathogen forms biofilms and uses a communication system called quorum sensing to produce virulence factors, which helps it resist antibiotics.* -
- The review focuses on targeting a specific quorum sensing system (RhlI/RhlR) with small molecules to inhibit biofilm formation and features recent studies on potential new anti-biofilm agents.*
Article Abstract
(. ) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. . forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in . , is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868144 | PMC |
| http://dx.doi.org/10.3390/antibiotics11020274 | DOI Listing |
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