AI Article Synopsis
- Senescence is a cellular response to stress that stops cell division and leads to a specific pattern of secretions linked to aging and related diseases.
- The transition to a senescent state involves complex factors, particularly the regulation of multiple genes through transcription.
- Epigenetic changes, such as alterations in chromatin structure, DNA methylation, and histone modifications, are key in initiating and sustaining cellular senescence and its secretory features.
Article Abstract
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes. Epigenetic alterations to DNA and chromatin are powerful regulators of genome architecture and gene expression, and they play a crucial role in mediating the induction and maintenance of senescence. This review will highlight the changes in chromatin, DNA methylation, and histone alterations that establish and maintain cellular senescence, alongside the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870565 | PMC |
| http://dx.doi.org/10.3390/cells11040672 | DOI Listing |
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