Reduction in Pathogenicity in Yeast-like Fungi by Farnesol in Quail Model.

was the first eukaryotic microorganism to exhibit quorum-sensing through the secretion of the sesquiterpene E, farnesol. This molecule is generated by dephosphorylation of farnesyl pyrophosphate in the mevalonate biosynthetic pathway in mammalian and yeast cells. Exogenous farnesol inhibits yeast-to-hyphal formation in a concentration- and time-dependent manner at the earliest stage of hyphal development. Much research has been devoted to studying the role of farnesol as an inhibitor of hyphal morphogenesis; however, little research has been published regarding the in vivo impacts of farnesol on fungal virulence and the development of infection. While other studies have examined the impact of multiple doses of farnesol in addition to antimycotics, we hypothesize that treated with a single dose of this quorum-sensing molecule could reduce fungal virulence in a quail model.