AI Article Synopsis
- - The study aimed to analyze and compare serum and fecal amino acid levels in cats with chronic kidney disease (CKD) to those in healthy cats, involving 35 CKD cats and 16 healthy control cats.
- - Results showed that CKD cats had significantly lower serum levels of several amino acids (like phenylalanine and tryptophan) and higher levels of others (such as aspartic acid and taurine) compared to healthy cats.
- - Despite differences in serum amino acids, fecal amino acid concentrations were similar between CKD and healthy cats, indicating that CKD affects serum amino acid profiles without significantly altering fecal levels.
Article Abstract
The purpose of the study was to quantify serum and fecal amino acids (AA) in cats with chronic kidney disease (CKD) and compare to healthy cats. Thirty-five cats with International Renal Interest Society Stage 1-4 CKD and 16 healthy mature adult and senior client-owned cats were included in this prospective cross-sectional study. Sera were analyzed for 25 AA concentrations using an ion exchange chromatography AA analyzer with post column ninhydrin derivatization. Voided fecal samples were analyzed for 22 AA concentrations using liquid chromatography with tandem mass spectrometry. CKD cats had lower serum concentrations of phenylalanine (mean difference ± standard error of the mean: 12.7 ± 4.3 µM; = 0.03), threonine (29.6 ± 9.2 µM; = 0.03), tryptophan (18.4 ± 5.4 µM; = 0.005), serine (29.8 ± 12.6 µM; = 0.03), and tyrosine (11.6 ± 3.8 µM; = 0.01) and higher serum concentrations of aspartic acid (4.7 ± 2.0 µM; = 0.01), β-alanine (3.4 ± 1.2 µM; = 0.01), citrulline (5.7 ± 1.6 µM; = 0.01), and taurine (109.9 ± 29.6 µM; = 0.01) when compared to healthy cats. Fecal AA concentrations did not differ between healthy cats and CKD cats. 3-Methylhistidine-to-creatinine did not differ between healthy cats with and without muscle loss. Cats with CKD IRIS Stages 1-4 have a deranged serum amino acid profile compared to healthy cats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878831 | PMC |
| http://dx.doi.org/10.3390/vetsci9020084 | DOI Listing |
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