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Toxicokinetics of Chromium in (Oligochaeta). | LitMetric

Toxicokinetics of Chromium in (Oligochaeta).

Toxics

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Published: February 2022

AI Article Synopsis

  • Chromium, while naturally occurring, can reach high levels in soil due to human activities, making its toxicokinetics crucial for understanding its toxicity and how it's absorbed and eliminated in organisms.
  • In a study, animals were exposed to 180 mg Cr/kg of dry soil for 14 days, followed by a 14-day period in clean soil, revealing rapid uptake and elimination rates of chromium.
  • The results indicated that animals can efficiently manage internal chromium levels and return to background concentrations within about 7 days after exposure, highlighting the need for further toxicokinetic research in assessing metal toxicity.

Article Abstract

Chromium is naturally occurring, but emission from anthropogenic sources can lead to increased soil concentrations. Information on its toxicokinetics is essential in order to understand the time needed to reach toxicity and the mechanisms of uptake/elimination. In this study the toxicokinetics of Cr(III) was evaluated using the soil standard species . The animals were exposed to 180 mg Cr/kg dry soil, a sublethal concentration, in LUFA 2.2 natural soil. OECD guideline 317 was followed, with a 14-day uptake phase in spiked soil followed by a 14-day elimination in clean soil. Exposure to Cr led to fast uptake and elimination, with = 0.012 kg/kg/day and = 0.57 day. The bioaccumulation factor was 0.022, and DT for elimination was 1.2 days. The concentration of Cr reached an internal equilibrium in the animals after 10 days. Transfer to clean soil allowed body Cr concentrations to return to background levels after approximately 7 days. seemed able to efficiently regulate internal Cr concentrations by actively eliminating Cr (an essential element). Although and deviated from the values reported in other studies for other soil invertebrates, the bioaccumulation factors were similar. These findings show the importance of toxicokinetic studies in evaluating toxicity based on internal metal concentrations that can more accurately represent the bioavailable concentration.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876269PMC
http://dx.doi.org/10.3390/toxics10020082DOI Listing

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