We investigate the orbital angular momentum of vortex light in a six-level atomic system with a closed loop. We find that a vortex light field via four-wave mixing (FWM) is sensitive to the relative phase of the driving fields due to forming a closed loop configuration. Thus, it could periodically tune the phase and intensity of the vortex FWM field by adjusting the relative phase of the driving fields. Moreover, the spatial modulation of the vortex FWM phase and intensity also can be achieved by tuning the intensity of the microwave field and detuning of the driving fields.
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Curr Cancer Drug Targets
January 2025
Division of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, 700114, India.
Immune checkpoint blockade (ICB) has fundamentally transformed cancer treat-ment by unlocking the potency of CD8+ T cells by targeting the suppression of the CTLA-4 and PD-1/PD-L1 pathways. Nevertheless, ICBs are associated with the risk of severe side effects and resistance in certain patients, driving the search for novel and safer immune check-point modulators. Monoamine Oxidase A (MAO-A) plays an unexpected role in the field of cancer.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Key Laboratory of Polyoxometalate and Reticular Material Chemistry of the Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.
Uranium (U), a high-performing, low-emission energy source, is driving sustainable economic growth. Herein, we synthesized two crystalline phases (HPOC-α and β) by an unreported amidoxime organic cage used for uranium capture. The revealed crystal structures and uranium adsorption test showed that accessible functional groups were essential to uranyl ions sorption.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Departments of Community Oral Health, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Different countries have varying dental specialities, shaped by diverse factors. The determinants influencing the development of these specialities differ between developed and developing countries. This study aimed to explore the factors contributing to the establishment of dental specialities in Iran, a developing country with a wide range of recognised dental specialities.
View Article and Find Full Text PDFAAPS PharmSciTech
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia, 30332-0100, U.S.A..
Delivery of therapies into skin is attractive for medical indications including vaccination and treatment of dermatoses but is highly constrained by the stratum corneum barrier. Microneedle (MN) patches have emerged as a promising technology to enable non-invasive, intuitive, and low-cost skin delivery. When combined with biodegradable polymer formulations, MN patches can further enable controlled-release drug delivery without injection.
View Article and Find Full Text PDFSci Rep
January 2025
Jilin Key Laboratory of Solid-State Laser Technology and Application, School of Science, Changchun, 130022, Jilin, China.
The response mechanism of a Four-Quadrant Photodetector (QPD) in an experimental setting was studied by irradiating a single QPD cell with a millisecond-pulsed laser. The response signal of the irradiated QPD cell varied with energy flux, pulse width, and applied bias, and comprised four main stages: an initial stage, decreasing barrier stage, holding stage, and recovery stage. Not only was the response signal of the irradiated cell affected by laser irradiation, but also the responses of the other three cells.
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