New Trichothecenes Isolated from the Marine Algicolous Fungus .

Eight trichothecenes, including four new compounds - and four known entities -, together with one known cyclonerane () were isolated from the solid-state fermentation of   NTU439 isolated from the marine alga . The structures of - were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound showed promising cytotoxic activity against all three cancer cell lines with the IC values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 μM, respectively. Compounds -, -, and - potently inhibited LPS-induced NO production, and compounds and showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.