Invasive fungal disease is a difficult to diagnose complication of therapy in patients with hematologic malignancy. Antifungal prophylaxis is recommended in high-risk populations, but its use in other populations is less clear. This brief report describes a patient with Trisomy 21 on caspofungin prophylaxis who died of disseminated Trichosporon asahii during induction therapy for new diagnosis low-risk B-cell acute lymphoblastic leukemia, accompanied by a review of similar cases in the literature. Her case highlights the utility of relatively novel diagnostic modalities and reinforces the need for caution in placing patients on antifungal prophylaxis.
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Article Synopsis
- Trichosporon asahii is a harmful fungus that primarily affects people with weakened immune systems, leading to severe infections.
- Researchers faced challenges in studying its virulence due to the absence of effective animal models and genetic tools specific to this fungus.
- The study introduces a new method using silkworms for infection testing and a genetic technique to create mutants, aiding in the discovery of virulence factors associated with T. asahii.
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