Deterministic particle transport codes usually take into account scattered photons with correct attenuation laws and application of buildup factor to incident beam. Transmission buildup factors for adipose, bone, muscle, and skin human tissues, as well as for various combinations of these media for point isotropic photon source with energies of .15, 1.5 and 15 MeV, for different thickness of layers, were carried out using Geant4 (version 10.5) simulation toolkit. Also, we performed the analysis of existing multilayered shield fitting models (Lin and Jiang, Kalos, Burke and Beck) of buildup factor and the proposition of a new model. We found that the model combining those of Burke and Beck, for low atomic number (Z) followed by high Z materials and Kalos 1 for high Z followed by low Z materials, accurately reproduces simulation results with approximated deviation of 3 ± 3%, 2 ± 2%, and 3 ± 2% for 2, 3, and 4 layers, respectively. Since buildup factors are the key parameter for point kernel calculations, a correct study can be of great interest to the large community of radiation physicists, in general, and to medical imaging and radiotreatment physicists, especially.
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http://dx.doi.org/10.1177/15593258211070911 | DOI Listing |
Mol Cell
December 2024
Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea. Electronic address:
Protein synthesis in the eukaryotic cytosol can start using both conventional methionine and formyl-methionine (fMet). However, a mechanism, if such exists, for detecting and regulating the incorporation of fMet (instead of Met) during translation, thereby preventing cellular toxicity of nascent fMet-bearing (fMet-) polypeptides, remains unknown. Here, we describe the fMet-mediated ribosome quality control (fMet-RQC) pathway in Saccharomyces cerevisiae.
View Article and Find Full Text PDFCureus
November 2024
Pharmacy/Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology (SRMIST), Chengalpattu, IND.
Atherosclerosis, a major cause of cardiovascular disease (CVD), involves plaque buildup in arteries driven by inflammation, endothelial dysfunction, and lipid metabolism disturbances. Current therapies aim to reduce cholesterol through statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, prevent blood clots with antiplatelet drugs like aspirin, and control inflammation, alongside lifestyle modifications. However, these approaches often fall short due to patient non-compliance and residual risks.
View Article and Find Full Text PDFNPJ Sci Food
December 2024
Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, 138668, Republic of Singapore.
Cultivated meat production offers solutions in addressing global food security and sustainability challenges. However, serum-free media (SFM) used in cultivating the cells are expensive, contributing to at least 50% of variable operating costs. This review explores technologies for cost-effective SFM, focusing on reducing cost from using growth factors and recombinant proteins, using affordable raw materials for basal media, and implementing cost-saving measures like media recycling and reducing waste build-up.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, School of Medicine, Hubei Polytechnic University, Hubei, China.
Atherosclerosis (AS) is a disease characterized by the buildup of fat and fibrous elements within the walls of arteries and is a primary factor in the occurrence of heart failure and mortality. The potential targets and mechanisms underlying the anti-atherosclerotic effects of avenanthramide (Avn) were investigated using network pharmacology, molecular docking, and molecular dynamics simulations. Target information for Avn A, B, and C was collected from the PubChem and Swiss Target Prediction databases.
View Article and Find Full Text PDFBMC Cardiovasc Disord
December 2024
Faculty of General Medicine, Department of General Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Background: Pericardial effusion (PE) indicates the build-up of fluid within the pericardial sac, which encases the heart. The present study was undertaken to assess the clinical profile, etiology of pericardial effusion and to determine the correlation of cardiac tamponade and constrictive pericarditis with etiology.
Methods: A prospective observational hospital based longitudinal study was undertaken among the 88 newly diagnosed and known patients of pericardial effusion who are above 18 years.
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