Artificial intelligence-based approaches for modeling the effects of spirulina growth mediums on total phenolic compounds.

Spirulina is a microalga and its phenolic compound is affected by growth mediums. In this study, Artificial intelligence (AI) based models, namely the Adaptive-Neuro Fuzzy Inference System (ANFIS) and Multilayer perceptron (MLP) models, and Step-Wise-Linear Regression (SWLR) were used to predict total phenolic compounds (TPC) of the spirulina algae. Spirulina productivity (P), extraction yield (EY), total flavonoids (TF), percent of flavonoid (%F) and percent of phenols (%P) are considered as input variables with the corresponding TPC as an output variable. From the result, TPC has a high positive correlation with the input variables with R = 0.99999. Also, the models showed that the ANFIS and SWLR gives superior result in the testing phase and increased its accuracy by 2% compared to MLP model in the prediction of TPC.