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Training it Forward: The Role of Embedded Research Fellows in the Network of Scholars Program in Nova Scotia Comment on "Early Career Outcomes of Embedded Research Fellows: An Analysis of the Health System Impact Fellowship Program".
Int J Health Policy Manag
December 2024
Nova Scotia Health Authority, Halifax, NS, Canada.
Kasaai et al describe the career trajectories of embedded scientists trained through the Health System Impact Fellowship (HSIF), showing that 37% of 2017-2019 HSIF alumni continue as embedded researchers in health systems. These findings suggest that the HSIF program effectively supports career readiness in health services and policy research (HSPR). Similarly, the Network of Scholars (NoS) program, launched post-pandemic in Nova Scotia, mirrors these results, with alumni continuing in embedded roles and mentoring a new cohort of learners from undergraduate to postgraduate levels.
View Article and Find Full Text PDFApproaches in landscape fire smoke pregnancy research and the impact on offspring: A review of knowledge gaps and recommendations.
Environ Pollut
January 2025
School of Medicine and Public Health, University of Newcastle, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
The increase in wildfires and bushfires due to climate change means that more people, including pregnant women and their fetuses will be exposed to landscape fire smoke. Although there is evidence to suggest that pregnancy landscape fire exposure is associated with lower birth weight, preterm birth and pregnancy loss, there is a lack of information on many other perinatal outcomes, as well as information on subsequent respiratory outcomes in children. Furthermore, due to the generally short term (hours/days) and intermittent nature of landscape fire smoke exposure, the knowledge to date has largely relied on natural experiments and ecological studies which can be subject to misclassification of exposure and a lack of precision.
View Article and Find Full Text PDFTissue Plasminogen Activator or Perfluoropropane for Submacular Hemorrhage in Age-Related Macular Degeneration: A Factorial Randomized Clinical Trial.
JAMA Ophthalmol
December 2024
King's Ophthalmology Research Unit, Ophthalmology Department, King's College Hospital, London, United Kingdom.
Importance: Evidence is limited to support therapies to treat submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (AMD) as an adjunct to anti-vascular endothelial growth factor therapy (anti-VEGF).
Objective: To determine if intravitreal tissue plasminogen activator (TPA) or gas improves visual acuity or promotes resolution of SMH secondary to neovascular AMD in eyes treated with ranibizumab.
Design, Setting, And Participants: This was a double-masked, sham-controlled, factorial randomized clinical trial and feasibility study that recruited participants from June 2014 to March 2019, with 12 months' follow-up.
Article Synopsis
- Clinical trials, essential for healthcare, also significantly contribute to climate change; researchers have developed a method to calculate their carbon footprint and applied it to 10 UK and international trials.
- Data on trial activities was collected from 10 trial units, evaluated for emission sources, and feedback was gathered on the carbon footprint calculation process.
- The carbon footprints of the trials varied widely, highlighting key areas for emissions reduction, with suggestions to incorporate carbon footprint considerations during the trial design phase.
Patterns of Brain Maturation in Autism and Their Molecular Associations.
JAMA Psychiatry
December 2024
Department of Child and Adolescent Psychiatry, University Hospital Goethe University, Frankfurt am Main, Germany.
Importance: In the neurotypical brain, regions develop in coordinated patterns, providing a fundamental scaffold for brain function and behavior. Whether altered patterns contribute to clinical profiles in neurodevelopmental conditions, including autism, remains unclear.
Objectives: To examine if, in autism, brain regions develop differently in relation to each other and how these differences are associated with molecular/genomic mechanisms and symptomatology.
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