AI Article Synopsis
- Researchers combined six resources to identify 6,083 potential druggable genes (PDGs) and analyzed their role in cancer development and treatment.
- They found that 81.5% of PDGs are expressed in major adult cancers, with 39.1% having recurring genetic changes, and 784 PDGs linked to cancer growth.
- The study also introduced a scoring system (PCDT score) indicating that high-scoring PDGs, often understudied, could offer new avenues for drug development in oncology.
Article Abstract
By combining 6 druggable genome resources, we identify 6,083 genes as potential druggable genes (PDGs). We characterize their expression, recurrent genomic alterations, cancer dependencies, and therapeutic potentials by integrating genome, functionome, and druggome profiles across cancers. 81.5% of PDGs are reliably expressed in major adult cancers, 46.9% show selective expression patterns, and 39.1% exhibit at least one recurrent genomic alteration. We annotate a total of 784 PDGs as dependent genes for cancer cell growth. We further quantify 16 cancer-related features and estimate a PDG cancer drug target score (PCDT score). PDGs with higher PCDT scores are significantly enriched for genes encoding kinases and histone modification enzymes. Importantly, we find that a considerable portion of high PCDT score PDGs are understudied genes, providing unexplored opportunities for drug development in oncology. By integrating the druggable genome and the cancer genome, our study thus generates a comprehensive blueprint of potential druggable genes across cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919705 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2022.110400 | DOI Listing |
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