By means of the reaction of inhibition of leucocytes adhesiveness, suggested by Halliday and his coworkers, the authors examined the immune reactivity of 52 oncological patients and 25 healthy donors. The specific cell activity was observed only in oncological patients, and mainly against the antigen from autologous or histologically identical tumor. In a third of patients under examination blood serum would block the specific cell activity. The intensity of the reaction was enhanced in immunotherapy with FHA activated lymphocytes. The sensitivity of the reaction involved proved to be higher than that of the reaction of lymphocytes migration inhibition by the same antigens.
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J Clin Med
December 2024
Department of Surgical Nursing, Medical University of Białystok, 15-274 Białystok, Poland.
Wound healing is a complex physiological process that begins immediately upon injury. Nutritional status significantly affects the course of regenerative processes. Malnutrition can prolong the inflammatory phase, limit collagen synthesis, and increase the risk of new wound formation.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
FLASH radiotherapy (FLASH RT) is an innovative modality in cancer treatment that delivers ultrahigh dose rates (UHDRs), distinguishing it from conventional radiotherapy (CRT). FLASH RT has demonstrated the potential to enhance the therapeutic window by reducing radiation-induced damage to normal tissues while maintaining tumor control, a phenomenon termed the FLASH effect. Despite promising outcomes, the precise mechanisms underlying the FLASH effect remain elusive and are a focal point of current research.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Anesthesiology, Cliniiques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Woluwé Saint-Lambert, Belgium.
Background: Hypnosis sedation has recently been used for anesthesia in breast oncologic surgery.
Methods: Between January 2017 and October 2019, 284 patients from our Breast Clinic (Cliniques Universitaires Saint-Luc, Université Catholique de Louvain) and from the Jolimont Hospital were prospectively included in an interventional non-randomized study approved by our two local ethics committees and registered on clinicaltrials.gov (NCT03330117).
Adv Sci (Weinh)
January 2025
The Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Xingangzhong Road 466, Guangzhou, 518037, P. R. China.
Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area.
View Article and Find Full Text PDFNanomaterials (Basel)
December 2024
Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Hypoxia, a phenomenon that occurs when the oxygen level in tissues is lower than average, is commonly observed in human solid tumors. For oncological treatment, the hypoxic environment often results in radioresistance and chemoresistance. In this study, a new multifunctional oxygen carrier, carboxymethyl hexanoyl chitosan (CHC) nanodroplets decorated with perfluorohexane (PFH) and superparamagnetic iron oxide (SPIO) nanodroplets (SPIO@PFH-CHC), was developed and investigated.
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