This study investigated the effect of denture liners surface modification with (EG) and (PG) on biofilm inhibition supposing its usage as a sustained-release therapeutical delivery system for -associated denture stomatitis. biofilm (SC5314 or ATCC 90028) was formed on soft liners superficially modified by a primer mixed to drugs at minimum inhibitory concentrations (0.100 g for EG and PG or 0.016 g for nystatin per ml of primer). After 24 h, 7 or 14 days, antibiofilm activity was evaluated by colony-forming unit counts. Not all groups were equi-efficient to nystatin after 24 h and 7 days. After 14 days, EG and PG efficacies were not different from nystatin (almost 100% inhibition). The proposed protocol presents a promising option to allopathic drugs for -associated denture stomatitis treatment.
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