AI Article Synopsis
- Photodynamic therapy (PDT) is gaining attention in antibacterial treatment for its selectivity and low risk of drug resistance.
- A new method called electroluminodynamic therapy (ELDT) combines electroluminescent materials with photosensitizers to produce reactive oxygen species (ROS) under an electric field for effective pathogen elimination.
- A portable, flexible therapeutic device made from hydrogel and integrated with a battery shows over 99.9% effectiveness against drug-resistant bacteria, suggesting ELDT as a promising alternative to traditional PDT.
Article Abstract
Photodynamic therapy (PDT) has attracted wide attention in antibacterial applications due to its advantages of spatial-temporal selectivity, noninvasiveness, and low incidence to develop drug resistance. To make it more convenient, universal, and manipulatable for clinical application, a conceptually antibacterial strategy, namely "electroluminodynamic therapy" (ELDT), is presented by nanoassembly of an electroluminescent (EL) material and a photosensitizer, which is capable of generating reactive oxygen species (ROS) in situ under an electric field, i.e., the fluorescence emitted by the EL molecules excites the photosensitizer to generate singlet oxygen ( O ), for the oxidative damage of pathogens. Based on the scheme of ELDT, a flexible therapeutic device is fabricated through a hydrogel loading with ELDT nanoagents, followed by integration with a flexible battery, satisfying the requirements of being light and wearable for wound dressings. The ELDT-based flexible device presents potent ROS-induced killing efficacies against drug-resistant bacteria (>99.9%), so as to effectively inhibit the superficial infection and promote the wound healing. This research reveals a proof-of-concept ELDT strategy as a prospective alternative to PDT, which avoids the utilization of a physical light source, and achieves convenient and effective killing of drug-resistant bacteria through a hydrogel-based flexible therapeutic device.
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| http://dx.doi.org/10.1002/adma.202200334 | DOI Listing |
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