AI Article Synopsis
- Tick-borne encephalitis virus (TBEV) is a zoonotic virus that leads to encephalitis in humans and has been linked to deletions in its genome's 3' untranslated region.
- A study using reverse genetics examined the impact of a specific Y-shaped secondary structure on the virus's pathogenicity.
- Deleting this structure resulted in higher mortality rates among infected mice but did not influence the virus's ability to reproduce in cultured cells or organs, suggesting it plays a role in TBEV's pathogenic regulation.
Article Abstract
Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes encephalitis in humans. Various deletions have been reported in a variable region of the 3' untranslated region of the TBEV genome. This study analyzed the role of a Y-shaped secondary structure in the pathogenicity of TBEV by using reverse genetics. Deletion of the structure increased the mortality rate of virus-infected mice but did not affect the virus multiplication in cultured cells and organs. The results indicate that the secondary structure is involved in the regulation of TBEV pathogenesis.
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| http://dx.doi.org/10.1111/1348-0421.12971 | DOI Listing |
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