AI Article Synopsis
- Current understanding of how COVID-19 affects cardiovascular health is still lacking, highlighting the urgent need for more research.
- A new mechanism involving red blood cells has been identified as a key factor in causing vascular issues in COVID-19 patients.
- Targeting reactive oxygen species or arginase 1 shows potential for improving these vascular problems, suggesting that balancing redox levels in red blood cells could help reduce complications from COVID-19.
Article Abstract
Current knowledge regarding mechanisms underlying cardiovascular complications in patients with COVID-19 is limited and urgently needed. We shed light on a previously unrecognized mechanism and unravel a key role of red blood cells, driving vascular dysfunction in patients with COVID-19 infection. We establish the presence of profound and persistent endothelial dysfunction in patients with COVID-19. Mechanistically, we show that targeting reactive oxygen species or arginase 1 improves vascular dysfunction mediated by red blood cells. These translational observations hold promise that restoring the redox balance in red blood cells might alleviate the clinical complications of COVID-19-associated vascular dysfunction.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849181 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2021.12.003 | DOI Listing |
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