It is every biochemist's dream to reconstitute a biological process in vitro using defined components, because doing so not only reduces a biological phenomenon to one or a series of biochemical reactions, but also defines the minimal list of essential components. In this issue of , Boreikaite and colleagues (pp. 210-224) and Schmidt and colleagues (pp. 195-209) report their independent reconstitution of human pre-mRNA 3' end processing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887131 | PMC |
| http://dx.doi.org/10.1101/gad.349453.122 | DOI Listing |
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