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Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults. | LitMetric

AI Article Synopsis

  • - The study investigated the link between obesity and early-onset cryptogenic ischemic stroke (CIS) in young adults, focusing on how fat distribution and gender might influence this relationship.
  • - In a sample of 345 young patients with acute CIS and an equal number of stroke-free controls, the research found a significant association between higher waist-to-hip ratios (WHR) and the risk of CIS, particularly in women.
  • - Results indicated that while WHR was a strong independent risk factor for CIS in young adults, other obesity measures like body mass index (BMI) and waist circumference did not show a similar association after controlling for various factors.

Article Abstract

Objectives: We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association.

Materials And Methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura.

Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS.

Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors.

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Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2022.106380DOI Listing

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