Piquing our interest: Insights into the role of PEAK3 in signaling and disease.

Sci Signal

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

Published: February 2022

Pseudokinases are critical signaling hubs that are increasingly appreciated as important disease targets. In this issue of , Hou bring new insights into the signaling mechanisms of the pseudokinase PEAK3 by characterizing its epidermal growth factor-dependent interactome and demonstrating oncogenic effects of PEAK3 overexpression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288111PMC
http://dx.doi.org/10.1126/scisignal.abm9396DOI Listing

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