Objective: To evaluate and compare the effectiveness of a mouth rinse with hydrogen peroxide (H O ) and hyaluronic acid (HA) versus a placebo mouth rinse on gingivitis.
Material And Methods: This was a 21-day, double blind, randomized, two-arm parallel allocation placebo-controlled trial of 50 study participants with a diagnosis of plaque-induced gingivitis. Patients were randomly allocated to the test group or the placebo group and were assessed at three time points over the course of the study by the same operator, at baseline (T0), 7 days (T1), and 21 days follow-up (T2). Primary outcomes of the trial were improvement in gingivitis and plaque accumulation.
Results: In both groups there was a decrease in gingival and plaque indices but the combination of the two actives (H O /HA) proved to be more effective against gingivitis (p = 0.001). Regarding plaque index, the differences between the test product and placebo were not statistically significant (p = 0.084). Besides, the new mouthwash was considered palatable, no adverse events were registered over the 21-day period.
Conclusions: The H O + HA product was more effective in reducing gingivitis when compared to a placebo while no differences were observed for plaque accumulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209803 | PMC |
| http://dx.doi.org/10.1002/cre2.498 | DOI Listing |
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