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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis.
Cancer Metab
January 2025
Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim, 68167, Germany.
Background: In malignant melanoma, liver metastases significantly reduce survival, even despite highly effective new therapies. Given the increase in metabolic liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), this study investigated the impact of liver sinusoidal endothelial cell (LSEC)-specific alterations in MASLD/MASH on hepatic melanoma metastasis.
Methods: Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated liver fibrosis, or a CDAA diet or a high fat diet (HFD) for shorter periods of time to induce early steatosis-associated alterations.
Using capacity assessments and tailored technical assistance to advance trauma informed care integration at the organizational level.
BMC Health Serv Res
January 2025
Cicatelli Associates Inc. (CAI), 505 8th Avenue, New York, NY, 10018, USA.
Background: The prevalence of trauma among individuals with HIV has prompted efforts to integrate trauma-informed care (TIC) into HIV care and treatment to improve health outcomes. A TIC Implementation Model, developed by a US capacity-building organization focuses on organizational changes, aligning cultural and physical environments, emphasizing values like safety and trustworthiness, engaging leadership, and training staff in skills-based TIC services. Despite growing research, gaps remain in understanding the relationship between organizational capacity, provider knowledge, and the dosage of technical assistance (TA) required to sustain TIC integration.
View Article and Find Full Text PDFBetula pendula Roth. survival and growth in treeline is affected by genotype and environment.
Sci Rep
January 2025
Department of Biology, University of Turku, 20014, Turku, Finland.
Alpine and Arctic treelines are assumed to be shifting toward higher latitudes and altitudes as a consequence of climate warming. Here, we compared the survival and growth of 1264 silver birch (Betula pendula Roth.) trees representing nine half-sib families.
View Article and Find Full Text PDFPlant interactions associated with a directional shift in the richness range size relationship during the Glacial-Holocene transition in the Arctic.
Nat Commun
January 2025
Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Polar Terrestrial Environmental Systems, 14473, Potsdam, Germany.
A nearly ubiquitous negative relationship between taxonomic richness and mean range-size (average area of taxa) is observed across space. However, the complexity of the mechanism limits its applicability for conservation or range prediction. We explore whether the relationship holds over time, and whether plant speciation, environmental heterogeneity, or plant interactions are major factors of the relationship within northeast Siberia and Alaska.
View Article and Find Full Text PDFArtificial Intelligence and Identification of the Deceased: a Narrative Review With Implications in Forensic Science.
Behav Sci Law
January 2025
Department of Anthropology, Panjab University, Chandigarh, India.
Identification of the dead is of utmost importance in mass disasters, war crimes, and forensic examinations. The biological profile, established by a forensic anthropologist is one the necessary steps involved in the identification of the dead. Several parameters can be estimated such as sex, age, stature, biogeographical affinity, and DNA profile of the unknown person.
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