AI Article Synopsis
- Antiretroviral therapy is effective in lowering viral loads for people with HIV, but treatment retention is crucial, especially in low-resource settings like Ethiopia.
- A study analyzed data from 542 registered HIV patients to determine the time and factors leading to loss of follow-up in antiretroviral therapy.
- The findings revealed a median follow-up time of 77 months, with significant predictors of lost to follow-up including poor adherence to medication, last functional status, and INH prophylaxis, highlighting the need for improved counseling and case management by healthcare providers.
Article Abstract
Antiretroviral therapy lowers viral load only when people living with HIV maintain their treatment retention. Lost to follow-up is the persistent major challenge to the success of ART program in low-resource settings including Ethiopia. The purpose of this study is to estimate time to lost to follow-up and its predictors in antiretroviral therapies amongst adult patients. Among registered HIV patients, 542 samples were included. Data cleaning and analysis were done using Stata/SE version 14 software. In multivariable Cox regression, a p-value < 0.05 at 95% confidence interval with corresponding adjusted hazards ratio (AHR) were statistically significant predictors. In this study, the median time to lost to follow-up is 77 months. The incidence density of lost to follow-up was 13.45 (95% CI: 11.78, 15.34) per 100 person-years. Antiretroviral therapy drug adherence [AHR: 3.04 (95% CI: 2.18, 4.24)], last functional status [AHR: 2.74 (95% CI: 2.04, 3.67)], and INH prophylaxis [AHR: 1.65 (95% CI: 1.07, 2.56) were significant predictors for time to lost to follow-up. The median time to lost was 77 months and incidence of lost to follow-up was high. Health care providers should be focused on HIV counseling and proper case management focused on identified risks.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861049 | PMC |
| http://dx.doi.org/10.1038/s41598-022-07049-y | DOI Listing |
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