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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899635 | PMC |
| http://dx.doi.org/10.1136/ejhpharm-2021-002762 | DOI Listing |
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Macrolide resistance due to (55).
Microbiol Spectr
January 2025
Institute for Microbial Systems and Society, Faculty of Science, University of Regina, Regina, Saskatchewan, Canada.
Unlabelled: Antimicrobial resistance (AMR) is a global threat. The identification and characterization of novel resistance genes is integral to AMR surveillance. The (55) gene was originally identified through whole genome sequencing of macrolide-resistant strains of .
View Article and Find Full Text PDFDraft genomes of fluoroquinolone-resistant subspecies strains isolated from Cambodian poultry marketplaces.
Microbiol Resour Announc
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Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
High-quality draft genomes of six subspecies strains from Cambodian poultry marketplaces were sequenced. The strains were identified as Corvallis-, Monschaui-, and Kentucky-serovars. The fluoroquinolone resistance gene, was found in three strains in different Cambodian provinces.
View Article and Find Full Text PDFNew Perspectives on Antimicrobial Agents: Omadacycline for community-acquired pneumonia, skin and soft tissue infections, and nontuberculous mycobacteria (focus on ).
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January 2025
Norton Infectious Diseases Institute, Norton Healthcare, Louisville, Kentucky, USA.
Omadacycline is a novel antimicrobial belonging to the tetracycline class. It has the ability to evade both efflux and ribosomal methylation types of resistance and therefore has an expanded spectrum compared to other tetracycline agents. Omadacycline is active against a number of multidrug-resistant bacteria, including macrolide and doxycycline-resistant methicillin-resistant (MRSA), vancomycin-resistant Enterococcus, and several enteric gram-negative bacilli.
View Article and Find Full Text PDFEvidence of dissemination of a -type integrative and conjugative element to , mediating acquisition of and other resistance determinants.
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Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
A strain positive for the metallo-beta-lactamase gene and resistant to trimethoprim-sulfamethoxazole was unexpectedly isolated from a surveillance rectal swab. The characterization of the strain revealed carriage of a 91 kb integrative and conjugative element (ICE) harboring several resistance determinants [, , , , ∆, , and ], closely related with a group of -type ICEs widespread among and other pseudomonads. Results highlighted the possible spreading of similar elements to , mediating the acquisition of relevant resistances.
View Article and Find Full Text PDFEnhanced bacteriostatic effects of phage vB_C4 and cell wall-targeting antibiotic combinations against drug-resistant .
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Yunnan Provincial Key Laboratory of Animal Nutrition and Feed, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
is a vital zoonotic pathogen known for its extensive drug resistance and ability to form biofilms, which contribute to its antibiotic resistance. In this study, the phage vB_C4, specifically targeting , was isolated and subjected to bioinformatic analysis and bacteriostatic activity assays. The combination of phage vB_C4 with antibiotics such as cephalothin and cefoxitin, which target the bacterial cell wall, resulted in a significantly enhanced bacteriostatic effect compared to either the phage or antibiotics alone.
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