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An Overview of Monkeypox Virus Detection in Different Clinical Samples and Analysis of Temporal Viral Load Dynamics.
J Med Virol
December 2024
School of Technology and Management, Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Leiria, Portugal.
Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV), and since May 2022, tens of thousands of cases have been reported in non-endemic countries. We aimed to evaluate the suitability of different sample types for mpox diagnostic and assess the temporal dynamics of viral load. We evaluated 1914 samples from 953 laboratory-confirmed cases.
View Article and Find Full Text PDFCo-Infectious Mystery: Why Artemether-Lumefantrine Cleared but Left behind.
Indian J Hematol Blood Transfus
October 2024
Centro Hospitalar Universitário Lisboa Norte Av. Prof. Egas Moniz MB, 1649-028 Lisbon, Portugal.
SPINE20 Recommendations 2024 -Spinal Disability: Social Inclusion as a Key to Prevention and Management.
Global Spine J
January 2025
Department of Orthopedics, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- Spine disorders are a major global disability issue, highlighting the need for improved access to high-quality spine care to foster social inclusion and dignity for affected individuals.
- SPINE20 outlines six recommendations for G20 countries, including providing evidence-based education for health workers, affordable spine care interventions, and investing in health policy research to support rehabilitation integration.
- Emphasizing the importance of social equity, SPINE20 urges collaborations among healthcare providers and policymakers to ensure comprehensive access to spine care, ultimately aiming to enhance population well-being and productivity.
Whole-brain annotation and multi-connectome cell typing of Drosophila.
Nature
October 2024
Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Article Synopsis
- The research focuses on the fruit fly Drosophila melanogaster as a crucial model in neuroscience, aided by extensive resources like the FlyWire whole-brain connectome and a hierarchical annotation of neuron classes and types.
- The study reveals 8,453 annotated cell types, with 4,581 being newly identified, highlighting the complexity of the fly brain and emphasizing the difficulty in reidentifying some hemibrain cell types in FlyWire.
- A new definition of cell type is proposed based on cell similarities across different brains, and the study illustrates findings related to neuron connectivity, structural stability, and a consensus atlas for the fly brain's neuroanatomy, supporting future comparative studies.
Neuronal wiring diagram of an adult brain.
Nature
October 2024
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Article Synopsis
- Researchers have created a detailed neuronal wiring diagram of the whole brain of a fruit fly (Drosophila melanogaster), mapping over 5 billion chemical synapses between more than 139,000 neurons, to better understand brain function.
- The study includes detailed annotations about various cell types, nerve pathways, and neurotransmitter identities, and the data is freely available for other researchers to use and explore.
- By analyzing synaptic pathways and connections, the project helps illustrate how neural structures relate to sensorimotor behaviors, paving the way for similar studies in other species.
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