Onco-hypertension: An Emerging Specialty.

Adv Chronic Kidney Dis

Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC; Renal Section, Durham VA Health Care System, Durham, NC. Electronic address:

Published: September 2021

Cancer is one of the leading causes of death worldwide. With the introduction of newer chemotherapeutic agents, targeted therapies, and immunotherapy, the prognosis and survival of patients with cancer has remarkably improved. As a result, patients are living longer and experiencing long-term cardiovascular complications. Hypertension is an important risk factor for cardiovascular diseases. Patients with malignancy have multiple etiologies of hypertension development, worsening, or association. This is because of the complex interplay between cancer type, chemotherapeutic agent, patient age, antihypertensive agent, and preexisting comorbidities in the etiology and pathogenesis of hypertension. Management of hypertension in patients with cancer requires accurate blood pressure measurement and considering factors such as adjuvant therapy and cancer-related pain. There are no set guidelines for management of hypertension in this unique cohort, and the therapy should be individualized based on the treatment guidelines for the general population. Onco-hypertension is an emerging subspeciality and entails a multidisciplinary approach between oncology, primary care physicians, nephrology, and cardiology.

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http://dx.doi.org/10.1053/j.ackd.2021.09.011DOI Listing

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Article Synopsis
  • Hypertension and cancer both increase with age, leading to the emergence of the concept "Onco-Hypertension," which focuses on the interconnected risks of these conditions in older patients.
  • Hypertension can contribute to the development of certain cancers, and cancer survivors are more likely to develop hypertension and face cardiovascular issues in the future.
  • The review discusses the current understanding and future directions of "Onco-Hypertension," along with the authors’ research findings on this topic.
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The prognosis of cancer patients has greatly improved in the last years, owing to the development of novel chemotherapeutic agents. However, this progress comes with an increasing occurrence of cardiovascular adverse reactions. A serious side effect is arterial hypertension (HT), which is the most frequent comorbidity encountered in cancer patients, influencing the outcomes in cancer survivors.

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Onco-hypertension: An Emerging Specialty.

Adv Chronic Kidney Dis

September 2021

Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC; Renal Section, Durham VA Health Care System, Durham, NC. Electronic address:

Cancer is one of the leading causes of death worldwide. With the introduction of newer chemotherapeutic agents, targeted therapies, and immunotherapy, the prognosis and survival of patients with cancer has remarkably improved. As a result, patients are living longer and experiencing long-term cardiovascular complications.

View Article and Find Full Text PDF

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