Aim: In our study, we examined the relationship between gastrointestinal system problems and adherence to immunosuppressant therapy after liver transplantation.
Method: We performed this study as descriptive and cross-sectional research with the participation of liver transplant recipients. In the data collection, we used the Personal Information Form, the Gastrointestinal Symptom Rating Scale, and the Immunosuppressant Therapy Adherence Scale. In the data analysis, we utilized the IBM Statistical Package for Social Science 25.0.
Findings: In our study, it was discerned that, of all liver transplant recipients (n = 331), 45.9% were aged 45-64 years, 77.3% were male, and 93.4% were married. Besides, 36.9% of liver transplant recipients were utilizing immunosuppressive agents for 1 month - 89 days. Next, it was identified that liver transplant recipients mostly used tacrolimus (67.4%), mycophenolate mofetil (65.6%), and prednisolone (76.7%). It was found that tacrolimus, mycophenolate mofetil, biological agents, and other immunosuppressants were associated with the development of gastrointestinal system problems.
Conclusion: The management of gastrointestinal system disorders is extremely importance to ensure that liver transplant recipients can adhere to immunosuppressant therapy. The awareness of liver transplant recipients about gastrointestinal system disorders and complications should be increased and their management should be assisted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.trim.2022.101554 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protein prenylation in mechanotransduction: implications for disease and therapy.
Trends Pharmacol Sci
January 2025
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:
The process by which cells translate external mechanical cues into intracellular biochemical signals involves intricate mechanisms that remain unclear. In recent years, research into post-translational modifications (PTMs) has offered valuable insights into this field, spotlighting protein prenylation as a crucial mechanism in cellular mechanotransduction and various human diseases. Protein prenylation, which involves the covalent attachment of isoprenoid groups to specific substrate proteins, profoundly affects the functions of key mechanotransduction proteins such as Rho, Ras, and lamins.
View Article and Find Full Text PDFAnorectal Botulinum Toxin Injection in Functional Constipation - The Jury is Still Out.
J Pediatr Surg
January 2025
Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, Brisbane, Australia. Electronic address:
Annual cholangitis more than twice predicts liver transplant in biliary atresia patients who achieve jaundice-free after Kasai portoenterostomy.
J Formos Med Assoc
January 2025
Division of Gastroenterology, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan; Liver Research Center, Linkou Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan Dist., Taoyuan City, 33305, Taiwan; Chang Gung University College of Medicine, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City, 33302, Taiwan. Electronic address:
Background: Biliary atresia (BA) is a progressive liver disease even after Kasai portoenterostomy (KPE), and the most common cause of liver transplant (LT) in the pediatric population. This study aimed to unveil the risk factors for LT in BA patients post-KPE.
Methods: We conducted a retrospective study of BA patients in a northern Taiwan Children's Medical Center from Jan 2000 to Oct 2020.
Circulating monocytes upregulate CD52 and sustain innate immune function in cirrhosis unless acute decompensation emerges.
J Hepatol
January 2025
Department of Biomedicine, University of Basel, Switzerland; University Centre for Gastrointestinal and Liver Disease Basel, Switzerland. Electronic address:
Background & Aims: Infectious complications determine the prognosis of cirrhosis patients. Their infection susceptibility relates to the development of immuneparesis, a complex interplay of different immunosuppressive cells and soluble factors. Mechanisms underlying the dynamics of immuneparesis of innate immunity remain inconclusive.
View Article and Find Full Text PDFHealthcare Costs and Early Complications in Liver-Transplanted Patients With Portal Vein Thrombosis: Experience From a Colombian Reference Center.
Value Health Reg Issues
January 2025
Facultad de Medicina, Universidad CES, Medellín, Antioquia, Colombia. Electronic address:
Objectives: This study aimed to analyze the direct healthcare costs and early complications associated with pretransplant portal vein thrombosis (PVT) in cirrhotic patients undergoing their first orthotopic liver transplant (LT) at a hospital in Colombia from 2013 to 2021.
Methods: A registry-based retrospective follow-up study was conducted on cirrhotic patients aged 14 years or older who underwent their first LT at the San Vicente Fundación Rionegro Hospital between January 2013 and April 2021. The primary outcomes were early (30-day) vascular and biliary complications and direct healthcare costs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!