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Clinical and microbiological characteristics of high-level daptomycin-resistant Corynebacterium species: A systematic scoping review.
J Infect Chemother
February 2025
Department of Infectious Diseases, Okayama University Hospital, Okayama, Japan; Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Introduction: Corynebacterium species potentially develop high-level daptomycin resistance (HLDR) shortly after daptomycin (DAP) administration. We aimed to investigate the clinical and microbiological characteristics of HLDR Corynebacterium infections.
Methods: We first presented a clinical case accompanied by the results of a comprehensive genetic analysis of the isolate, and then performed a systematic scoping review.
Salt-Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.
Macromol Biosci
January 2025
Department of Chemistry, Paderborn University, Warburger Str. 100, 33098, Paderborn, Germany.
Article Synopsis
- A new strategy has been developed for creating multifunctional surfaces using multiblock copolymers, which combine antifouling and antibacterial properties.
- The copolymers include a polyzwitterionic block that prevents protein attachment and a polycationic block that eliminates bacteria upon contact, with a central block that anchors the material to titanium oxide surfaces.
- Testing showed the surfaces can regenerate by rinsing with salt, effectively clear adhering proteins, and kill bacteria like Staphylococcus aureus and Escherichia coli, pointing towards potential applications in creating safer medical implants.
Ruminant stimulating device-associated esophageal obstruction in a Japanese black heifer with acquired esophageal diverticulum.
Vet Res Commun
November 2024
Laboratory of Clinical Veterinary Medicine for Large Animals, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Esophageal diseases include esophageal obstruction, esophagitis, esophageal stricture, and esophageal diverticulum. Imaging can facilitate the selection of appropriate treatment options and assist in differential diagnosis. Esophageal obstruction in cattle is generally caused by greedy nature of chewing and swallowing of food and foreign structures, including stones, potatoes, trichobezoar, carrots, foodstuffs (i.
View Article and Find Full Text PDFSuccessful Treatment of Recurrent Extensively Drug-Resistant Bacteremia Secondary to Ventricular Assist Device-Associated Infection.
Open Forum Infect Dis
November 2024
Division of Infectious Diseases, Department of Medicine, Northwestern University, Chicago, Illinois, USA.
is an emerging pathogen increasingly implicated in health care-associated infections. Here, we report a case of recurrent ventricular assist device-associated infection caused by multidrug-resistant and describe the clinical course, treatment challenges, and ultimate case resolution. Our results demonstrate that standard clinical methodologies for determining trimethoprim-sulfamethoxazole minimum inhibitory concentration, including VITEK2 and gradient diffusion tests, may be unsuitable for as they result in false-negative susceptibility results.
View Article and Find Full Text PDFThe Opportunistic Pathogen : Virulence and Antibiotic Resistance, Clinical Features, Association with Orthopedic Implants and Other Medical Devices, and a Glance at Industrial Applications.
Antibiotics (Basel)
October 2024
Laboratory of Immunorheumatology and Tissue Regeneration, Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
In recent decades, the risk of developing opportunistic infections has increased in parallel with the ever-increasing number of people suffering from chronic immunosuppressive diseases or undergoing prosthetic surgery. is a Gram-positive and coagulase-negative bacterium. Usually found as a component of the healthy human and animal microbiota of the skin and mucosae, it can take on the role of an opportunistic pathogen capable of causing a variety of infections, ranging from mild to life-threatening, not only in immunocompromised patients but even, although rarely, in healthy people.
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