Aim: To provide in-depth understanding of real-world tumor necrosis factor inhibitor (TNFi) treatment patterns in patients with ankylosing spondylitis (AS) and treatment satisfaction, productivity loss, and associated factors.
Methods: This was a multicenter observational hybrid retrospective chart review and cross-sectional survey study. Disease activity and physical functioning were measured using the Bath AS Disease Activity Index and Bath AS Functional Index, respectively. Treatment satisfaction was determined with the Treatment Satisfaction Questionnaire for Medication (TSQM). Productivity loss was evaluated using the Korean version of the World Health Organization-Health and Work Performance Questionnaire.
Results: A total of 497 patients were enrolled (mean age 40.3 years, 85.3% male, mean AS duration 10 years). The mean duration of TNFi treatment was 6.2 years. Among the four TNFi considered, adalimumab (39.6%) and etanercept (23.5%) were most commonly used at study enrollment. The TSQM convenience domain score was lower than scores in the effectiveness, adverse effects, and global satisfaction domains. Subcutaneous syringe-type injection and intravenous injection were associated with lower patient convenience satisfaction than subcutaneous pen-type injection. Increased costs of lost productivity time were associated with female sex, unemployed status, and higher disease activity.
Conclusions: The most frequently prescribed TNFi was adalimumab, followed by etanercept. Etanercept was used for the longest duration. More convenient treatment options may enhance overall treatment satisfaction. Considerable loss in productivity due to AS was observed in this study. To reflect patients' perspectives, further attention should be paid to factors associated with treatment satisfaction and productivity loss when selecting treatment options.
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http://dx.doi.org/10.1111/1756-185X.14304 | DOI Listing |
Pak J Med Sci
January 2025
Meijin Yuan Department of Nursing, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
Objective: To explore the clinical efficacy of the interactive humanistic nursing model in emergency rescue of epidemic outbreaks.
Methods: This was a retrospective study. A total of 200 patients with novel coronavirus pneumonia (NCP) admitted to The First Affiliated Hospital of Hebei North University between December 2022 and March 2023 were selected and divided into the observation group(n=100) and the control group(n=100) according to different nursing methods used.
Cureus
December 2024
Critical Care, Unidade Local de Saúde de Lisboa Ocidental, Lisbon, PRT.
Purpose: As the population ages, critically ill older adults increasingly face complications and require more healthcare resources during hospitalization. Since post-ICU (intensive care unit) mortality is an important consideration, particularly in elderly populations, this study aims to assess whether advanced age impacts ICU and post-ICU mortality by comparing outcomes between patients aged 81 years and above with those below 81 years.
Methods: This retrospective study analyzed data from 3,821 ICU patients treated at the Unidade Local de Saúde de Lisboa Ocidental between 2015 and 2023.
Cureus
December 2024
Prosthodontics, Government Dental College, Kozhikode, IND.
Background: Digital dentistry has transformed all aspects of dentistry, especially prosthodontics, and is increasingly used for diagnosis, treatment planning, execution, student training, and research. This study aimed to assess the perception, attitude, and practice of digital technology in prosthodontics among dental professionals in Kerala, India.
Materials And Methods: A cross-sectional, questionnaire-based study was conducted among dental professionals in Kerala.
Cureus
December 2024
Internal Medicine, Luminis Health Anne Arundel Medical Center, Annapolis, USA.
Background Daily interdisciplinary rounds in hospitals are becoming standardized to maximize the multidisciplinary approach to hospitalized patient care. We hypothesize that structured Interdisciplinary Bedside Rounds (IDRs) increase the satisfaction, education, and experience of medical staff and thus detail actionable recommendations for IDR implementation or delineate measurable long-term impacts. Methods This observational study was performed in a 300-bed community hospital.
View Article and Find Full Text PDFInt J Nephrol Renovasc Dis
January 2025
Astellas Pharma Singapore Pte. Ltd, Singapore, Singapore.
Introduction: Limited data exist regarding treatment patterns and symptom burden of patients with anemia of chronic kidney disease (CKD) in the Middle East, South Africa, and Türkiye.
Methods: This real-world study explored clinical characteristics, symptom burden, and treatment patterns of patients with anemia of CKD living in the Middle East, South Africa, and Türkiye. Physician and patient perceptions of treatment were captured via cross-sectional surveys; patients' clinical characteristics were recorded by retrospective review of medical records.
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