Background: Critically ill trauma and surgical patients often fail to achieve adequate enteral nutrition (EN) support. We hypothesize that implementation of an evidence-based, multidisciplinary nutrition enhancement protocol (EP) will improve delivery of EN in critically ill trauma and surgical patients and align our institution with nationally recommended guidelines.
Methods: The study compared patients prior to protocol (PP) with patients after implementation of the EP. The primary outcome was delivery of >80% of daily prescribed EN kilocalories in critically ill trauma and surgical patients during their intensive care unit stay. Data were prospectively captured from daily rounds and the electronic health record. Statistical analysis was conducted to compare data between groups using Student t test for continuous variables and chi-square test for categorical variables.
Results: In total, 256 patients in the PP group (2663 EN days) were compared with 232 patients in the EP group (2059 EN days). The primary outcome of average percentage of nutrition delivered (based on 24-h kilocalorie requirements) improved after the implementation of the EP (75.3% PP vs 85.5% EP; P < 0.01). This improvement was evident in surgical (69.9% PP vs 78.7% EP; P < 0.01) and trauma (78.2% PP vs 87.3% EP; P < 0.01) subpopulations. The secondary outcome of percentage of patients receiving >80% of nutrition goal also improved (52.7% PP vs 65.2% EP; P < 0.01).
Conclusion: Implementation of an EP significantly increased delivery of EN by 10.2% and achieved compliance with American Society for Parenteral and Enteral Nutrition and Society of Critical Care Medicine recommended guidelines for critically ill trauma and surgical patients.
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http://dx.doi.org/10.1002/jpen.2353 | DOI Listing |
BMJ Open
January 2025
Department of Clinical Nutrition,School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Introduction: There is currently limited information regarding the association between the modified Nutrition Risk in Critically Ill (mNUTRIC) score, nutrition delivery and clinical outcomes in critically ill patients admitted to the intensive care unit (ICU) section.
Methods And Analysis: The Isfahan-ICU study is a multicentre, prospective observational cohort study that will be conducted on critically ill adults treated in the trauma or medical ICU sections of six hospitals to investigate whether clinical outcomes, including length of ICU stay and 30-day survival, vary by the mNUTRIC score at admission or the 7-day nutrition delivery. This paper outlines the Isfahan-ICU study protocol approved by the ethics committee of Isfahan University of Medical Sciences, Iran.
BMJ Open Gastroenterol
January 2025
Department of Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Objective: It is controversial whether rapid lowering of triglyceride (TG) levels is associated with clinical benefits in patients with hypertriglyceridaemia-associated acute pancreatitis (HTG-AP). In particular, patients with different severity of disease may respond differently to TG-lowering therapy. In this study, we aimed to explore the association between rapid decline in serum TG levels and organ failure in patients with different severities of HTG-AP.
View Article and Find Full Text PDFBMJ Open
January 2025
Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, Minnesota, USA
Introduction: Propofol is a widely used sedative-hypnotic agent for critically ill patients requiring invasive mechanical ventilation (IMV). Despite its clinical benefits, propofol is associated with increased risks of hypertriglyceridemia. Early identification of patients at risk for propofol-associated hypertriglyceridemia is crucial for optimising sedation strategies and preventing adverse outcomes.
View Article and Find Full Text PDFAust Crit Care
January 2025
Critical Care Research Group, Prince Charles Hospital, Brisbane, Queensland, Australia; School of Dentistry, University of Queensland, Brisbane, Queensland, Australia.
Background: Many intensive care unit (ICU) survivors experience new or worsening impairments, termed post-intensive care syndrome. Substantial investment has been made in identifying patients at risk and developing interventions, but evidence remains equivocal. A more nuanced understanding of risk and outcomes is therefore warranted.
View Article and Find Full Text PDFSchizophr Bull
January 2025
Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China.
Background And Hypothesis: Identifying biomarkers at onset and specifying the progression over the early course of schizophrenia is critical for better understanding of illness pathophysiology and providing novel information relevant to illness prognosis and treatment selection. Studies of antipsychotic-naïve first-episode schizophrenia in China are making contributions to this goal.
Study Design: A review was conducted for how antipsychotic-naïve first-episode patients were identified and studied, the investigated biological measures, with a focus on neuroimaging, and how they extend the understanding of schizophrenia regarding the illness-related brain abnormality, treatment effect characterization and outcome prediction, and subtype discovery and patient stratification, in comparison to findings from western populations.
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