Hydrogen sulfide (HS) has been regarded as the third endogenous gas signaling molecule. The development of suitable tools for HS detection in vitro and in vivo has always been a focus of research. In this work, three BODIPY-NBD dyads (o/m/p-BNP) were designed and synthesized using BODIPY and NBD as the fluorophore and quencher, respectively. The position of the NBD moiety in the probe showed different fluorescence quenching abilities. All probes showed highly selective to HS. Probe o-BNP displayed the maximum fluorescence enhancement (c.a. 1300-fold) and the lowest detection limit (105 nM). Probe o-BNP can visualize the production of endogenous HS in HeLa cells and zebrafish.
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| http://dx.doi.org/10.1016/j.saa.2022.121007 | DOI Listing |
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